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publicado em 01/07/2013 às 14h41:00
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Largest project in the world loose 430 million modified Aedes aegypti in Bahia

Will be released into the environment four million males genetically modified per week over 3 years

 
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Foto: James Gathany/UC Davis
Release of male mosquito Aedes aegypti is a genetically modified disease efficient technique
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Release of male mosquito Aedes aegypti is a genetically modified disease efficient technique

A new stage design Transgenic Aedes (PAT), which frees males genetically modified to combat wild insect, that transmits dengue, was started in the city of Bahia Jacobina. Will be released approximately 4 million mosquitoes a week for the next three years to combat dengue. Result of an agreement between the Institute of Biomedical Sciences (ICB) and the USP biofactory Moscamed Brazil, PAT will release in this new stage, more than 430 million mosquitoes.

"This is a pioneering project in the world. Nowhere was made a release of transgenic mosquitoes that size, the researcher afima ICB, Margareth Lara Capurro, coordinator of PAT. Lineage insect used was developed by British scientists Company Oxitec, partner in the project, and is prouzida Unit Production of Transgenic Aedes Moscamed in Juazeiro, today with a weekly production of approximately 1 million males.

The release of male mosquito Aedes aegypti is a genetically modified disease efficient technique. Between October 2011 and September 2012, the first edition of PAT gave about 17 million GM mosquitoes in two districts of the municipality of Juazeiro (Bahia) carrying the wild population of the insect suppression. The idea is that if we reduce the mosquito population, hence is able to reduce the transmission of disease, the researcher Margaret.

Due to changes in specific genes of mosquitoes, eggs laid in the environment, generated from the cross between transgenic and wild females, inherit a gene that prevents lethal to develop until adulthood. According to biologist Danilo de Oliveira Carvalho, who is also part of the project the gene responsible for the mortality of larvae and pupae have their operation depends on the presence or absence of a type of antibiotic called tetracycline.

In the absence of the substance and activates gene produces a protein that modifies the rates of protein synthesis (transcription followed by translation) of larval cells, accumulating and leading to her death. In turn, when there tetracycline this process is blocked. The larva stops accumulating activator and develops, says Carvalho. This is what happens when this strain of mosquitoes is produced in a controlled laboratory.

On the recommendation of the Secretary of Health of the State of Bahia Jacobina was chosen for the second phase of the PAT. With about 49,000 inhabitants in the urban area, the city had a major outbreak of dengue in 2011 with 2 deaths and over 1,600 cases of the disease identified. The first release of GM mosquitoes in the city of Jacobina took place on June 18 this year. According to Margaret, the releases will be divided into areas. Unlike previous experience in Juazeiro, the initial steps happen in areas with smaller wild populations of Aedes aegypti, creating a sort of barrier, and then expand to other areas. As this time the release will take place throughout the city, will also try to observe how the interference in the transmission of dengue, the teacher provides.

The first step <b> </ b>

The first stage of PAT in five communities from Juazeiro. The choice was made according to the size of wild populations of Aedes aegypti in these places, and geographical issues, such as certain isolation, so as to avoid interference as migration of insects, which could adversely affect the results of measurements of releases.

After a period of clarification of the local population on the action and initial tests to verify dispersal and reproduction capacity of the crops are being released about 500 000 males per week. Before release, the average index wild mosquito population was 40%, measured from traps, calls ovitraps that attract the insect. After six months of release, the rate dropped to 6%. However, Danilo says that after the end of the releases to the wild population began to rise again, although the new index has not yet been calculated. This indicates that we have to maintain clearances at baseline to keep the population down, says.

With information from USP Agency

Source: Isaude.net
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dengue    Aedes Transgenic Project    PAT    Aedes aegypti    Institute of Biomedical Sciences    USP    Brazil biofactory Moscamed    Margareth Lara Capurro   
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