Science and Technology
publicado em 28/06/2013 às 11h00:00
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Device prevents secondary surgery after undergoing mastectomy

Technical creates breast tissue sample can be examined 20 minutes after removal, eliminating the need for reoperation

 
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When a breast tumor is detected, many women opt to have a lumpectomy, which is surgery designed to remove the diseased tissue while preserving the breast. But during this procedure, doctors cannot learn right away whether all of the cancerous tissue has been removed, with no microscopic signs that cancer cells were left behind. Because of this delay, one in five of these women up to 66,000 patients annually in the U.S. alone must return for a second surgery to remove remaining cancer. These follow-up operations boost healthcare costs and can lead to delays in receiving other treatments such as radiation and chemotherapy.

To reduce the need for these second surgeries, four Johns Hopkins graduate students have designed a device to allow pathologists to quickly inspect excised breast tissue within 20 minutes, while the patient is still in the operating room. If this inspection indicates that the tumor was not fully removed, additional tissue can then be removed during the same operation. Eliminating the need for a second operation could also curb some of the additional anxiety these patients face.

The device to reduce repeated breast cancer surgeries was developed by Johns Hopkins students, from left, Hector Neira, Vaishakhi Mayya, Qing Xiang Yee and Anjana Sinha. At right, James Shin, a surgical pathology research specialist, was one of their advisers. Photo by Will Kirk/homewoodphoto.jhu.edu

The device is still in its prototype stage, but the students say their goal is to give breast cancer patients the same rapid review that commonly occurs when tumors are removed from elsewhere in the body. The students learned about the second-surgery dilemma while observing medical procedures last summer as part of a year-long biomedical engineering master' s degree program. In this program, students learn to design new medical tools and products that address urgent healthcare needs.

" We spoke to breast cancer surgeons," said Hector Neira of Silver Spring, Md., one of the student inventors. " They told us that they are desperate for something that will allow them to remove the tumor in its entirety the first time, so that the patient doesn' t have to come back for a second surgery."

So far, the team' s system has been tested on animal tissue and human breast samples from a tissue bank, but it has not yet been used on patients. Over the past year, however, the students' device design and market analysis have earned them more than $40,000 in college business plan prize money. In the recent Design Day event for Johns Hopkins biomedical engineering students, the team received the top People' s Choice award. And, although all of the student inventors received their master' s diplomas in May, two have received funding to remain at Johns Hopkins and continue refining the project over the coming year.

Although the financial support and recognition is helpful, " that' s not our ultimate goal," said Anjana Sinha of Princeton, N.J., another one of the student inventors. " We' re not doing it for the money. We want to improve healthcare practices and raise the standard of care for these breast cancer patients. Why can' t they get the same type of quick results that people with other types of cancer receive?"

The students' device applies an adhesive film to the breast tissue before it is sliced for examination. The film prevents damage to the samples. Photo by Will Kirk/homewoodphoto.jhu.edu

When most tumors are removed, such as those in the liver, the pathology staff can quickly flash-freeze the tissue and slice off paper-thin samples for microscopic examination. If the pathologist sees that cancer cells extend to the outer edge or margin of a sample, the surgeon is advised to remove more tissue from the patient. But breast tissue poses a problem: it possesses a high fat content and does not freeze well, causing the samples to smear, form gaps and become unsuitable for a quick review. Instead, breast tissue must be preserved and analyzed in a more time-consuming process that requires the patient to return to the operating room if the first surgery appears to have left cancer cells behind.

To solve this problem, the graduate students brainstormed for an engineering solution. Their most promising and practical idea was a device that applies an adhesive film to the breast tissue before it is sliced. The film holds the delicate tissue together, preventing damage to the samples during the slicing process. The result, the students said, is a sample that can be clearly reviewed by a pathologist within 20 minutes of its removal, potentially eliminating the need for a second operation on another day.

The low-cost system includes a reusable applicator and a proprietary disposable film. The students said the need for their product is significant, citing the estimated 330,000 lumpectomies that are performed annually in the U.S. alone.

" I think the students have been incredibly creative in their development of this concept, and they are addressing a very real need in the field of breast cancer surgery," said Melissa Camp, a Johns Hopkins assistant professor of surgery who worked with the students. " Accurate assessment of margin status during the initial operation will lead to fewer re-operations, and this will be beneficial for patients in many respects. I look forward to their continued work!"

Source: JOHNS HOPKINS UNIVERSITY
   Palavras-chave:   Mastectomy    Breast Cancer    Breast Tissue    Johns Hopkins University    Hector Neira   
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