General
publicado em 21/06/2013 às 10h15:00
   Dê o seu voto:

Two weeks of treatment prevents development of epilepsy

Research offers hope for the production of new effective medicines to relieve the symptoms and recurrent seizures

 
font size
A-
A+

Temporal lobe epilepsy, the most common form of epilepsy, is characterized by recurrent seizures throughout life and often behavioral abnormalities, with devastating impacts on patients and their families. Unfortunately, the condition is often not responsive to anticonvulsants. Now scientists report online June 20 in the Cell Press journal Neuron that targeting a particular signaling pathway in mice can prevent the development of temporal lobe epilepsy with just two weeks of treatment, offering hope that researchers will be able to develop effective drugs to mitigate recurrent seizures and the development of epilepsy. Many patients with temporal lobe epilepsy experience an initial episode of prolonged seizures, known as status epilepticus, which is often followed by a period of seizure-free recovery before individuals develop recurring seizures. Research in animals suggests that the prolonged seizures in status epilepticus cause or contribute to the development of epilepsy.

"An important goal of this field has been to identify the molecular mechanism by which status epilepticus transforms a brain from normal to epileptic," says Dr. James McNamara, of the Duke University Medical Center in Durham. "Understanding that mechanism in molecular terms would provide a target with which one could intervene pharmacologically, perhaps to prevent an individual from becoming epileptic."

In a mouse model of temporal lobe epilepsy that develops after status epilepticus, Dr. McNamara and his colleagues found that inhibiting the BDNF receptor, TrkB,using genetic modification of the animal to make it susceptible to chemical disruption of TrkB action at a specific time prevents the development of epilepsy as well as associated anxiety behaviors and loss of neurons. Remarkably, a two-week treatment to block TrkB activity after the initial seizure was capable of exerting long-term protective effects.

"This demonstrated that it is possible to intervene following status epilepticus and prevent the animal from becoming epileptic," says Dr. McNamara. The findings also indicate that targeting TrkB for only a limited period of time is capable of achieving successful treatment of epilepsy without the need for lifelong therapy. This highlights TrkB as a promising target for the design of drugs to prevent epilepsy development.

Source: Isaude.net
  • Share this pageShare this page
  • Share this pageCorrect
  • ShareShare
  • AlertAlert
Reduced link: 
  • You are recommending this story: Two weeks of treatment prevents development of epilepsy
  • Fill in the following form to send your recommendation to your friend:

  • You are suggesting a correction for this story: Two weeks of treatment prevents development of epilepsy


Receba notícias do iSaúde no seu e-mail de acordo com os assuntos de seu interesse.
Seu nome:
Seu email:
Desejo receber um alerta com estes assuntos:
Epilepsy Treatment 2 weeks    epileptic seizures    Duke University Medical Center    James McNamara   
Comments:
Comment
Leave your comment
Close
(Required fields are marked with an *)

(Your email address will never be published or shared.)

Enter the letters and numbers below and click in the button "send"

  • Twitter iSaúde
advertising
Informe Saúde printed version

Recommend the portal
Close [X]
  • You are recommending this story: http://www.isaude.net
  • Fill in the following form to send your recommendation to your friend:

RSS news from the portal  iSaúde.net
Get the newsletter of the portal  iSaúde.net
Recommend the portal iSaúde.net
News from  iSaúde.net in your blog or website.
Get news on the subject of your interest.
© 2000-2011 www.isaude.net Todos os direitos reservados.