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publicado em 05/06/2013 às 17h30:00
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Novel procedure recreates pancreas function in the bone marrow

Doctors in Italy recovered endocrine cells of a pancreas removed due to diabetes and "rebuilt" in the spinal

 
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Italian doctors have recreated part of the function of the pancreas in the bone marrow of four patients for the first time in the world, a statement from San Raffaele hospital in Milan said on Wednesday.

A team of researchers from the Italian northern hospital conducted the ground-breaking operation on patients with type 3c diabetes who had their pancreases removed due to illness, the statement said.

By modifying the procedure normally used for transplantation of pancreatic islets in patients with type 1 diabetes, the team recovered endocrine cells from the pancreas surgically removed "rebuilding" it in the bone marrow at the level of the pelvis thus obtaining a sort of "puzzle organ," it added.

The endocrine tissue took root and worked, in an observation period of almost three years, demonstrating that the procedure was safe and effective, the head of the Pancreatic Islet Transplantation Program and Beta Cell Biology Unit at the Diabetes Research Institute of San Raffaele, Lorenzo Piemonti, noted.

According to the researchers, preventing the onset of after-surgery diabetes with the use of autologous tissue was an "innovative concept offering a new therapeutic approach to patients with pancreas diseases." The results were published in a study in the Diabetes medical journal.

Piemonti said his team wished that the bone marrow microenvironment may also be used in patients with type 1 diabetes undergoing allogeneic transplantation form organ donors.

"Thanks to this first experience, we have been able to begin a clinical trial in these patients and, presumably, we will have the first results starting from the next year," he said.

Source: Isaude.net
   Palavras-chave:   Pancreas    Bone marrow    Diabetes    Hospital San Raffaele    Lorenzo Piemonti   
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