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publicado em 09/05/2013 às 01h40:00
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Substance used for hypertension is effective in the treatment of schizophrenia

Results showed greater efficacy in control of all symptoms, and faster action and no side effects

 
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Foto: Marcos Santos/USP Imagens
About 1% of the world population suffers from schizophrenia, according to the World Health Organization (WHO).
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About 1% of the world population suffers from schizophrenia, according to the World Health Organization (WHO).

Joint research between the Faculty of Medicine of Ribeirão Preto (FMRP), USP and Research Unit of Neurochemistry, University of Alberta, Canada, gets new treatment for schizophrenia. Results showed greater efficacy in control of all your symptoms, and faster action and no side effects. The findings of the research, led by Professors Jaime Hallak, FMRP, and Serdar Dursun, Alberta, just published in the journal Archives of General Psychiatry / Psychiatry JAMA.

The drugs available today, according to the researchers, brought only partial improvements and acted mainly in delusions and hallucinations of patients, but had very discrete action, or not acting on other symptoms, such as negative and cognitive. Thus began testing a treatment with a previously known substance, sodium nitroprusside, which is used in severe systemic hypertension.

After extensively tested in animals studied for three years its action in humans, which showed the acute phase of the disease, indicating hospitalization and up to five years of diagnosis. These patients were admitted to the Hospital of the FMRP and, after a week of taking the medicines prescribed by their doctors, who still had symptoms of the disease were divided into two groups. The first group received placebo and the other medication based on sodium nitroprusside.

The results were striking in those that received sodium nitroprusside, shows Hallak. He says that there was a decrease in all acute symptoms of schizophrenia in the first hours of infusion. These patients were evaluated during the 4-hour infusion after 12 and 24 hours after 7 and 28 days and continued to improve. And, most importantly, had no side effects. Including pressure remained normal celebrates.

Sodium nitroprusside is a type of salt that nitric oxide donating nitrergic system, or is a vasodilator that acts on the periphery of the vascular system. But in case of schizophrenia, researchers' interest was the central action (central nervous system).

Several discussions on the pathophysiology of schizophrenia, which had concluded that there was a dysfunction of the glutamatergic system in patients with the disease, were the starting point for research. This often acts glutamatergic system using nitric oxide as intermediate or as a second or third messenger. Then, if a decrease of some function that glutamatergic neurotransmitter system, decrease the production of nitric oxide. Thus, after reviewing studies that bring this evidence, we hypothesized that nitric oxide was replaced, there would be a reversal of the symptoms of schizophrenia. And that was precisely what happened, says Professor Hallak.

About 1% of the world population suffers from schizophrenia, according to the World Health Organization (WHO). The disease is chronic, has no cure and affects the person at the time that everyone expects their bloom, late adolescence.

According to Professor Hallak, in the last 60 years have seen great advances in the reduction of side effects of drugs that treat schizophrenia, but the effectiveness is still small. These drugs, says, act mainly in the dopaminergic system. These drugs are very good for so-called positive symptoms such as delusions and hallucinations, for example, the patient has a partial improvement and treatment results slow to appear. They are not good in the cognitive, the affective and negative schizophrenia.

For the study was published, the researchers assessed the patients who received sodium nitroprusside to the 28th day of treatment. However, new studies conducted by the group provide evidence that the improvement lasts at least three months. We are now moving to the repeated dose study, reveals the teacher.

Experts say that, apart from the specific treatment efficacy, these results pave the way for research in the same line for curative treatments of schizophrenia. These results are proof that there are more effective treatments and that it is possible to think of cure for schizophrenia. Some groups are researching ways to identify early markers increasingly providing the appearance of the disease. Thus, these people may get too early treatment with drugs, for example, this row. Thus the chance of preventing the onset and hence the progression of the disease is very large. We are paving the way not only for medicine but also for research on pathophysiology, the causes of schizophrenia.

<i> Agency information USP </ i>

Source: Isaude.net
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sodium nitroprusside    Faculty of Medicine of Ribeirão Preto    USP    Research Unit of Neurochemistry    University of Alberta    Canada    Jaime Hallak    Serdar Dursun    Hospital of the FMRP   
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