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publicado em 02/05/2013 às 12h31:00
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Researchers from Unicamp create dental anesthesia without injection

The painless anesthesia is an old dream of dental professionals and considered the "Holy Grail" of the profession

 
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Foto: Marcos Santos/USP Imagens
Research done at Unicamp aims to create a gel or anesthetic cream that dispenses a pinprick mouth lining
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Research done at Unicamp aims to create a gel or anesthetic cream that dispenses a pinprick mouth lining

A team of researchers from the Institute of Biology, State University of Campinas (Unicamp) developed an anesthetic cream, in order to dispense with the use of the needle in dental procedures.

"The dental anesthesia painless and needle is an old dream of dental professionals and considered by many the, Holy Grail, the profession." Eneida de Paula explains project coordinator. She adds that, "the proposal was not produce new molecules anesthetic, since it would require at least ten years of development and clinical trials."

The purpose of the research was to increase the effectiveness of anesthetic salts available in the market to encapsulate them within carriers or nanoparticles, capable of taking the active ingredients to the desired location and release them in a controlled manner.

The research began in 2007 with choosing the ideal carrier for each anesthetic. "He could not cause adverse reactions in the body, would have to be chemically stable and need to keep the local anesthetic applied as long as possible," he said. Paula

Liposomes, particles made from lipids and similar to biological membranes, were tested by the first carrier group. According to the researcher, the liposomes are able to take anesthetics without generating adverse reactions and are already employed by the pharmaceutical industry in antivirals, antifungals and developing vaccines and anticancer drugs.

The researcher says that liposomes provide an environment similar to the molecular site of action of local anesthetic. "In addition, its chemical properties attract these drugs, which are retained in their membranes, preventing them from being absorbed rapidly beyond the site of action," he says.

Tests in animals and humans have shown that the use of liposomes as carriers (solvent) prolonged time of action of anesthetics mepivacaine and prilocaine three to four times compared to commercial drugs which act for two to four hours. This efficiency, however, still depend on the use of syringes in the application of the drug.

Source: Isaude.net
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oral anesthesia    painless dental anesthesia    anesthetic    anesthetic cream    liposome carriers    solvents    State University of Campinas       
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