publicado em 23/04/2013 às 20h15:00
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Polymeric nanoparticles and silver are used in the healing of burns

Treatments quelled the inflammatory process and possible care for burn injuries

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A treatment with silver nanoparticles and polymer is used in the healing of burns. Research conducted at Unicamp, by biologist Larissa Barbosa Paula tested silver nanoparticles produced by biotechnological method using the fungus Fusarium oxysporum, and polymeric nanoparticles coated with chitosan and containing S-nitrosoglutathione (GSNO). Their conclusion was that such treatments quelled the inflammatory process and possible care for burn injuries.

In laboratory animals after 14 days of treatment with gels containing nanoparticles, the polymer showed a reduction in wound diameter larger than that of silver (AgNP). However, with seven days of treatment (21 days), the framework is reversed: the diameter of the wounds treated with AgNP was smaller than that of polymeric nanoparticles. But both healed well, the researcher says.

At the end of the 35 days of treatment, the control group (who received only the gel) wound still signaled, whereas in the groups treated with the nanoparticle systems, the wounds had been healed, and in some animals came to register the growth of hair follicles (hair).

The silver nanoparticles were produced extracellularly by Fusarium oxysporum, has mechanisms (not fully elucidated) to reduce silver ions when exposed to a solution containing this metal. Spherical nanoparticles are highly stable and high antimicrobial activity is essential in the treatment of burns, once the infection is a major clinical complications of this type of injury. The biologist said that the methods used in their study already existed, but "innovation was on account of its application to wounds caused by burns.

At the same time, it consists of a compound encapsulated glutathione and nitric oxide (GSNO) nanoparticles prepared with a biocompatible and biodegradable polymer-coated by chitosan (which also has high antimicrobial activity.) One major advantage of this system is to protect the drug within the organism and achieve a sustained release, eliminating the need for reapplication and becoming an alternative to long-term therapies.

The GSNO, already tested in chronic wounds such as diabetic patients, also never been tested in burns and showed great potential for healing in the experiments. The coating with chitosan, a second master's degree, and provide antimicrobial activity, allows better retention of nanoparticles in mucosal surfaces, sustained release of the active ingredient encapsulated.

The treatment is most often used in hospitals cream based on silver sulfadiazine 1%. However, after application, it is customary to occlude the wound with gauze. By requiring frequent changes, this type of treatment becomes very uncomfortable and painful for paciente.Alguns products such as oily lotions based on essential fatty acids, gauze impregnated with aloe vera and polyurethane membranes, options are less painful by not adhere to the wound. However, they are mostly imported, raising the costs of large-scale use in therapy centers for burnt. It is estimated that the Unified Health System (SUS) annually spend about U.S. $ 55 million treatments of these patients.

The biomedical both said nanoparticles were applied to the animals twice daily, in the form of a gel which was subsequently absorbed by the body, as well as polymeric nanoparticles. It is one of the methods used in the cosmetic and pharmaceutical industry for the preparation of ointments and creams, as it is inert to the body. It is used as a vehicle for substances explains.

The main indication of gels containing nanoparticles developed by the biomedical be for the treatment of severe burns and some small to medium length. It would be impractical for the treatment of an injury which affected 80% of the body, which would require very large amounts of product. Very severe burns and / or extensive can also affect the lungs and other vital organs, further decreasing the life expectancy of the patient, being necessary measures quicker reinforces Larissa.

According to the World Health Organization (WHO), the burns are one of the major public health problems. In Brazil, it is estimated that one million accidents occur with thermal burns each year. There are only 10% of hospitalization and about 2500 deaths in all age groups, according to information from the Brazilian Society of Burns (SBQ). Burns are also among the primary causes of death from external causes behind violent, such as traffic accidents and homicides.

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Silver nanoparticles    Fusarium oxysporum    polymeric nanoparticles coated with chitosan    S-nitrosoglutathione    Unicamp   
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