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publicado em 04/04/2013 às 10h19:00
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Baldness increases risk of coronary heart disease in men

New data suggest that men with hair loss at the crown were 70% more likely to have atherosclerosis

 
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To confirm the association between male pattern baldness and coronary heart disease (CHD) scientists from Tokyo used m eta-analysis of observational studies.

Medline and the Cochrane Library were searched for articles published up to November 2012 using keywords that included both ' baldness' and ' coronary heart disease' and the reference lists of those studies identified were also searched.

Observational studies were identified that reported risk estimates for CHD related to baldness. Two observers independently assessed eligibility, extracted data and assessed the possibility of bias.

The adjusted relative risk (RR) and 95% CI were estimated using the DerSimonian-Laird random-effect model.

possible studies, 3 cohort studies and 3 case control studies were selected (36?990 participants). In the cohort studies, the adjusted RR of men with severe baldness for CHD was 1.32 (95% CI 1.08 to 1.63, p=0.008, I2=25%) compared to those without baldness. Analysis of younger men (<55 or ?60?years) showed a similar association of CHD with severe baldness (RR 1.44, 95% CI 1.11 to 1.86, p=0.006, I2=0%). In three studies employing the modified Hamilton scale, vertex baldness was associated with CHD and the relation depended on the severity of baldness (severe vertex: RR 1.48 (1.04 to 2.11, p=0.03); moderate vertex: RR 1.36 (1.16 to 1.58, p<0.001); mild vertex: RR 1.18 (1.04 to 1.35, p<0.001)). However, frontal baldness was not associated with CHD (RR 1.11 (0.92 to 1.32, p=0.28)).

Vertex baldness, but not frontal baldness, is associated with an increased risk of CHD. The association with CHD depends on the severity of vertex baldness and also exists among younger men. Thus, vertex baldness might be more closely related to atherosclerosis than frontal baldness, but the association between male pattern baldness and CHD deserves further investigation.

Source: Isaude.net
   Palavras-chave:   Baldness    Hair loss    Heart disease    University of Tokyo   
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