publicado em 01/04/2013 às 20h40:00
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Unicamp moth clinical profile carrier of Chagas Disease

Research shows that most patients are elderly, hypertensive and use many medicines

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Research developed at the Faculty of Medical Sciences (FCM) revealed that elderly patients by the Study Group on Chagas Disease, Hospital de Clinicas da Unicamp are mostly aged between 60 and 69 years are hypertensive and make use of drugs for treatment of several other diseases. The analysis done by biologist Mariane Barroso Pereira showed that the cardiac form of the disease is more prevalent among patients.

According to her, the elderly with chronic diseases require greater care, as there is a possibility of other problems that come with advancing age. A biologist remembers that disease, discovered in 1909, already had the vector path as their main form of transmission. With the control of the authorities, the incidence of new cases decreased, causing a change in the characteristics of the infected population.

Currently, the chagasic population in Brazil consists mainly by patients with the chronic form of the disease. These individuals are aging and require appropriate clinical follow-up, ie, it is one more reason to know the profile explains.

To learn the history of the regulars of the Group, the biologist conducted interviews with 85 patients and collected testimonies during consultations. Much could not remember when or how it would have been bitten by the barber or triatomine insect transmitting the parasite, but many had a history in the family. In general, a first-degree relative also had the disease, and the respondents were migrants from endemic regions of the insect. The prevalence of polypharmacy, according Mariane, was high. In 34% of the elderly were observed using various medications. In many cases, the patient took five or more drugs for treating other diseases.

A second phase of the research consisted of surveys conducted in the Laboratory of Molecular Diagnosis of Infectious Diseases by Molecular Biology Techniques. The test was able to detect the existence of the parasite in only 36% of patients. The low positivity in the test may reveal that there is a small amount of parasitic disease in the majority of volunteers. This is a good result but needs a deeper, explains study author. This result was only possible thanks to the use of molecular biology to identify the presence of DNA of Trypanosoma cruzi.

Carriers have long found themselves in the chronic phase of the disease and living with evil for at least fifty years. For the tests, blood samples were collected and, according Mariane, perform molecular examination in the samples was the big difference in your search. The technique applied in this profile carriers of Chagas Disease is unprecedented. The blood sample was submitted to a DNA extraction and amplification of the core region gene of the parasite. It is a time consuming and examination techniques are very sensitive. Sets. It further states that this type of test may be used in conjunction with other tests to aid in detecting the disease.

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clinical profile of Chagas disease    clinical profile    Chagas disease    Faculty of Medical Sciences    Hospital das Clinicas    Unicamp   
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