Science and Technology
publicado em 01/04/2013 às 12h57:00
   Dê o seu voto:

U.S. team creates artificial spleen to treat bloodstream infections

Unit will be used to eliminate bacteria, viruses, and toxins from the blood and improve the treatment of sepsis

 
font size
A-
A+
Foto: Wyss Institute
Foto: Wyss Institute
Dispositivo será usado para tratar infecções da corrente sanguínea em pacientes criticamente enfermos e soldados feridos em combate Tecnologia faz uso de proteínas sanguíneas especializadas
  « Previous
next »  
Dispositivo será usado para tratar infecções da corrente sanguínea em pacientes criticamente enfermos e soldados feridos em combate
Tecnologia faz uso de proteínas sanguíneas especializadas

The Wyss Institute for Biologically Inspired Engineering at Harvard University announced today that it was awarded a $9.25 million contract from the Defense Advanced Research Projects Agency (DARPA) to further advance a blood-cleansing technology developed at the Institute with prior DARPA support, and help accelerate its translation to humans as a new type of sepsis therapy.

The device will be used to treat bloodstream infections that are the leading cause of death in critically ill patients and soldiers injured in combat.

To rapidly cleanse the blood of pathogens, the patient's blood is mixed with magnetic nanobeads coated with a genetically engineered version of a human blood 'opsonin' protein that binds to a wide variety of bacteria, fungi, viruses, parasites, and toxins. It is then flowed through microchannels in the device where magnetic forces pull out the bead-bound pathogens without removing human blood cells, proteins, fluids, or electrolytes -- much like a human spleen does. The cleansed blood then flows back to the patient.

The technology makes use of specialized blood proteins and magnetic forces to pull pathogens from the blood. [Credit: Wyss Institute]

"In just a few years we have been able to develop a suite of new technologies, and to integrate them to create a powerful new device that could potentially transform the way we treat sepsis," said Wyss founding director and project leader, Don Ingber, M.D., Ph.D. "The continued support from DARPA enables us to advance our device manufacturing capabilities and to obtain validation in large animal models, which is precisely what is required to enable this technology to be moved towards testing in humans."

The team will work to develop manufacturing and integration strategies for its core pathogen-binding opsonin and Spleen-on-a-Chip fluidic separation technologies, as well as a novel coating technology called "SLIPS," which is a super-hydrophobic coating inspired from the slippery surface of a pitcher plant that repels nearly any material it contacts. By coating the inner surface of the channels of the device with SLIPS, blood cleansing can be carried out without the need for anticoagulants to prevent blood clotting.

Source: UNIVERSIDADE DE HARVARD
  • Share this pageShare this page
  • Share this pageCorrect
  • ShareShare
  • AlertAlert
Reduced link: 
  • You are recommending this story: U.S. team creates artificial spleen to treat bloodstream infections
  • Fill in the following form to send your recommendation to your friend:

  • You are suggesting a correction for this story: U.S. team creates artificial spleen to treat bloodstream infections


Receba notícias do iSaúde no seu e-mail de acordo com os assuntos de seu interesse.
Seu nome:
Seu email:
Desejo receber um alerta com estes assuntos:
Spleen artificial    bloodstream infections    sepsis    Wyss Institute for Biologically Inspired Engineering    Don Ingber   
Comments:
Comment
Leave your comment
Close
(Required fields are marked with an *)

(Your email address will never be published or shared.)

Enter the letters and numbers below and click in the button "send"

  • Twitter iSaúde
advertising
Informe Saúde printed version

Recommend the portal
Close [X]
  • You are recommending this story: http://www.isaude.net
  • Fill in the following form to send your recommendation to your friend:

RSS news from the portal  iSaúde.net
Get the newsletter of the portal  iSaúde.net
Recommend the portal iSaúde.net
News from  iSaúde.net in your blog or website.
Get news on the subject of your interest.
© 2000-2011 www.isaude.net Todos os direitos reservados.