Research unveils action of endotoxins in infections in the dental pulp

Study of the Khanate dentist Frederick Martin, State University of Campinas (Unicamp), unveiled the action of endotoxins in infections in the dental pulp. The results of the study point to the need of adopting a contemporary endodontic therapy more effective, based on the eradication of infection, both of micro-organisms, which involves microbiological point of view, as the endotoxin from them.

The research involved the use of different endodontic maneuvers - such as use of specific techniques and substances - used in the reduction or elimination of micro-organisms and endotoxins and also monitoring the inflammatory potential of these endotoxins.

According to Professor Brenda Paula Figueiredo de Almeida Gomes, guiding research, unlike the work presented in endodontic literature, the research aimed to identify not only the profile endodontic infectious disease, but simultaneously assess the activity and potential inflammatory endotoxic content against different endodontic treatment protocols recommended by professionals.

This was a clinical trial, involving patients therefore, the integrated cell immunobiology, which used various methods of microbial identification, detection and quantification of endotoxins and monitoring of proinflammatory cytokines.

The data obtained allow establishing a connection between the laboratory findings and clinical features of patients: the bigger the load of endotoxin, increased inflammatory response, increased pain and consequently the severity of disease.

<i> information Unicamp </ i>

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