publicado em 15/03/2013 às 13h59:00
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Search Search new method for transplants and skin graft

Laboratory Imunomorfologia Paulista State University uses pigskin and protein therapy for transplant

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Using pigskin and therapy with the protein annexin A1, a team of researchers from the Universidade Estadual Paulista (UNESP) seeks to develop a new method for transplants and skin graft, necessary when there is loss of skin and appendages caused by non-healing wounds or from postsurgical complications, hernias complicated withdrawal, cancer or severe burns.

The technique consists of using sows who suffered removal in laboratory cell and nucleic much material, but with no effect on its biological activity and its mechanical integrity.

Initial results from tests on rats according Sonia have shown that the biological material is easily manipulable and adjustable to the surface of the host, providing an appropriate filler and incorporation into the fabric with little reaction of the organism.

We note, therefore, that one way to improve transplants and implants is the use of a material of natural origin, non immunogenic and which provides the necessary adhesion to the reconstruction of the skin, the professor explains Sonia Oliani, study coordinator. Also, another benefit is the fact that this was a material economically viable.

The acellular porcine are produced in London, primarily with supervision of researcher Karin Greco at Northwick Park Institute For Medical Research, University College London, Institute which works in partnership with the Laboratory of Imunomorfologia Ibilce. Besides analyzing the occurrence of rejection, the team of Black River has made the characterization of the porcine acellular biochemical point of view, biomechanical and structural.

Another key point of the research is the analysis of annexin A1 as a potential therapeutic use in regenerative and healing processes. Such a protein that is produced by the body and has important physiological roles, including anti-inflammatory actions have been successfully used in renal transplantations performed at laboratory.

We have numerous studies, also in partnership with the British University Queen Mary University of London, show that annexin A1 as a major weapon in inflammatory processes, says Sonia.

However, there is no evidence that the effects of annexin A1 can be translated in control of the immune response in cases of rejection of tissues. Our purpose now is to reach this understanding as an alternative to improve the quality and survival of skin grafts in patients.

<i> information Unesp </ i>

   Palavras-chave:   Skin graft    Pigskin    Annexin A1    UNESP    University of São Paulo   
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