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publicado em 18/02/2013 às 12h36:00
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Cola inspired by mussels prevents preterm birth and improved chemotherapy

Material can be used for the repair and amniotic membrane as polymer for the transport of anticancer drugs

 
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Foto: Andreas Trepte
Species of mussel Mytilus edulis used in the study
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Species of mussel Mytilus edulis used in the study

Materials that mimic natural adhesive produced by mussels to keep them glued to the rocks may help prevent preterm delivery and improve the effectiveness of chemotherapy. It reveals that the study by researchers at Northwestern University, USA.

Research suggests that the material may be used for the repair and amniotic membrane as polymers for transporting drugs to treat tumors.

The adhesion of mussels is a remarkable process that involves secretion of a protein liquid which hardens rapidly in the form of an adhesive solid and water resistant. Various aspects of this natural process inspired us to develop synthetic materials. One important application may be in the repair of body tissues, in which water is present quite difficult and attempts at treatment, the researcher claims Phillip B. Messersmith.

The feet of the common mussel (Mytilus edulis species) produce a sticky adhesive capable of adhering to rocks and other surfaces found in aquatic environments. Key component of this capability is a unique family of proteins that contain high concentration of the amino acid DOPA (dihydroxyphenylalanine), whose synthetic form was produced by researchers.

In a pregnancy, premature rupture of the amniotic membrane can occur spontaneously or in conjunction with a surgical procedure. The membranes have limited ability to recover these disruptions and the result is often premature delivery or other serious complications. The synthetic polymer developed by U.S. researchers acts as a liquid glue that solidifies and adheres to damp fabric membrane, correcting the problem.

Messersmith has been conducting studies in collaboration with European scientists to conduct experiments in vivo for repair of breaks in the fetal membrane.

Another application of the synthetic adhesive can carry antitumor drugs acting in forming drug vehicles for stable and inactive in the bloodstream. PH-sensitive site, these particles are activated by means of the areas with more acidic tumors, where they release drugs.

Source: Isaude.net
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Mussel glue    preterm delivery    amniotic membrane    chemotherapy    Northwestern University    Phillip B. Messersmith   
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