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Evolution of antiretroviral drugs for AIDS treatment is recorded in book

Analysis of USP professor recounts developments since the advent of antiretroviral AZT up to today

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An analysis of Mario Scheffer, professor in the Department of Preventive Medicine, Faculty of Medicine, University of São Paulo (USP), the book Cocktail: the incredible story of antiretrovirals and treatment of AIDS in Brazil, discusses the evolution of the treatment of the disease in Brazil.

In the first part of the book, Scheffer recounts the evolution of antiretroviral drugs since the emergence of AZT (zidovudine), in 1986, until the present day and also elata trajectory of incorporation therapy in the Unified Health System (SUS).

According to Sheffer, the Brazilian program to fight AIDS, providing universal free provision of antiretroviral drugs in public, is considered one of the most successful in the world. But to suit the current context, it would be necessary to double the number of patients seen - only possible with the scaling up HIV testing, greater investment in generic and adopting an aggressive stance in negotiating prices of imported drugs.

<b> The great revolution </ b>

Before AZT, AIDS was a death sentence. In 1991, there are other drugs of the same class and opened dual therapy also benefit ephemeral. It was in 1995 when it emerged a new class of drugs known as protease inhibitors, there was a great revolution in the treatment, he said.

At this time, continues Scheffer found that, when combining drugs acting at different stages of HIV replication, it was possible to control the virus. The concept of the AIDS cocktail and becomes potentially a chronic disease.

The disease affected a population already at the beginning stigmatized and therefore organized to fight for their rights. Thanks to intense mobilization of NGOs and policy environment in 1996 was making the right decision to create a federal law to enforce the obligation of the SUS to provide treatment, recalled Scheffer.

The researcher points out that, in addition to investing in domestic production capacity, we need to improve the trading price of imported drugs and discuss the possibility of being broken new patents. Brazil today pay more than other countries. The Ministry of Health is the only buyer, and therefore has the meat and potatoes on hand for the regular price.

The book brings together research conducted by Scheffer during his doctorate and post-doctorate, the latter with support from FAPESP and guidance of Professor Ayres FMUSP Euclides de Castilho. Adds yet the author's experience as an activist in the fight against AIDS since 1988.

   Palavras-chave:   AIDS    Antiretroviral    AZT    Medicines    Scheffer    Zidovudine    FAPESP   
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