General
publicado em 30/12/2012 às 10h00:00
   Dê o seu voto:

New study links protein-producing breast milk to breast cancer

Discovery may open new opportunities for the treatment of most common and lethal form of cancer among women

 
font size
A-
A+
Foto: Acutez Media
Mãe amamentando
  « Previous
next »  
Mãe amamentando

Australian scientists have shown how a ' transcription factor' causes breast cancer to develop an aggressive subtype that lacks sensitivity to oestrogen and does not respond to anti-oestrogen therapies such as Tamoxifen and aromatase inhibitors.

Transcription factors are molecules that switch genes on or off. In this case, the transcription factor known as ' ELF5' inhibits sensitivity to oestrogen very early in the life of a breast cancer cell.

In 2008, Associate Professor Chris Ormandy from Sydney' s Garvan Institute of Medical Research showed that ELF5 was responsible for the development of the oestrogen-receptor-negative cells in the breast during pregnancy that produce milk.

In the current study Ormandy, in collaboration with Drs Maria Kalyga and David Gallego-Ortega, has shown that the same molecular decision occurs in breast cancer and that ELF5 has the ability to change an existing tumour to an oestrogen-insensitive type.

The team has also described the genetic mechanisms by which ELF5 opposes the action of oestrogen, and has shown that it is possible to alter the subtype of breast cancer by manipulating ELF5 levels. The findings are published in the highly prestigious journal PLoS Biology, now online.

" This work tells us that cancers which become refractory to anti-oestrogen treatment often do so by elevating their levels of ELF5 and becoming functionally oestrogen receptor negative," said Ormandy.

" This raises the therapeutic option of manipulating ELF5 levels to treat breast cancer."

" As ELF5 is intracellular, this could possibly be done with small molecule therapies that target protein-to-protein interactions, or with small inhibitory RNAs."

" There is also the possibility of testing ELF5 levels in tumours to predict response to treatment and therefore guide treatment decisions."

" Our key discovery here is that by simply manipulating one transcription factor we can change the subtype of breast cancer."

Source: Isaude.net
   Palavras-chave:   Breast milk    Breast cancer    Garvan Institute of Medical Research    Chris Ormandy   
  • Share this pageShare this page
  • Share this pageCorrect
  • ShareShare
  • AlertAlert
Reduced link: 
  • You are recommending this story: New study links protein-producing breast milk to breast cancer
  • Fill in the following form to send your recommendation to your friend:

  • You are suggesting a correction for this story: New study links protein-producing breast milk to breast cancer


Receba notícias do iSaúde no seu e-mail de acordo com os assuntos de seu interesse.
Seu nome:
Seu email:
Desejo receber um alerta com estes assuntos:
Breast milk    breast cancer    Garvan Institute of Medical Research    Chris Ormandy   
Comments:
Comment
Leave your comment
Close
(Required fields are marked with an *)

(Your email address will never be published or shared.)

Enter the letters and numbers below and click in the button "send"

  • Twitter iSaúde
advertising
Informe Saúde printed version

Recommend the portal
Close [X]
  • You are recommending this story: http://www.isaude.net
  • Fill in the following form to send your recommendation to your friend:

RSS news from the portal  iSaúde.net
Get the newsletter of the portal  iSaúde.net
Recommend the portal iSaúde.net
News from  iSaúde.net in your blog or website.
Get news on the subject of your interest.
© 2000-2011 www.isaude.net Todos os direitos reservados.