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publicado em 22/12/2012 às 15h00:00
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Taste receptors in the intestine can be targets for obesity prevention

Research suggests that approach may in future mimic physiological effects of a meal and trick the body

 
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Despite more than 25 years of research on antiobesity drugs, few medications have shown long-term success. Now researchers reporting online on December 21 in the Cell Press journal Trends in Endocrinology & Metabolism say that targeting taste sensors in the gut may be a promising new strategy.

The gut "tastes" what we eat bitter, sweet, fat, and savory in much the same way as the tongue and through the use of similar signaling mechanisms. The result is the release of hormones to control satiety and blood sugar levels when food reaches the gut. The sensors, or receptors, in the stomach respond to excess food intake, and their malfunction may play a role in the development of obesity, diabetes, and related metabolic conditions.

Drs. Sara Janssen and Inge Depoortere, of the Translational Research Center for Gastrointestinal Disorders at the Catholic University of Leuven, Belgium, examine this possibility, offering insights into the latest research on the topic. They say growing evidence suggests that obesity and related conditions might be prevented or treated by selective targeting of taste receptors on cells in the gut to release hormones that signal a feeling of fullness, thereby mimicking the physiological effects of a meal and fooling the body into thinking that it has eaten.

"The effectiveness of bariatric surgery to cause profound weight loss and a decrease in the prevalence of diabetes and other obesity-related conditions is not completely understood, but it may involve changes in the release of gut hormones," says Dr. Depoortere. "Targeting extraoral taste receptors that affect the release of hormones that control food intake may offer a new road to mimic these effects in a nonsurgical manner."

Additional studies are needed to show which gut taste receptors might be effective drug targets for the prevention and treatment of obesity and diabetes.

Source: Isaude.net
   Palavras-chave:   Obesity    Diabetes    Taste receptors in the gut    Satiety    Catholic University of Leuven    Sara Janssen   
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