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publicado em 19/12/2012 às 11h25:00
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Chinese scientists discover that gut bacteria can cause obesity

Mice resistant to obesity gained weight after received injections with the removal of intestinal enterobacteria obese person

 
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Lipopolysaccharide endotoxin is the only known bacterial product which, when subcutaneously infused into mice in its purified form, can induce obesity and insulin resistance via an inflammation-mediated pathway.

Here we show that one endotoxin-producing bacterium isolated from a morbidly obese human' s gut induced obesity and insulin resistance in germfree mice.

The endotoxin-producing Enterobacter decreased in relative abundance from 35% of the volunteer' s gut bacteria to non-detectable, during which time the volunteer lost 51.4 kg of 174.8 kg initial weight and recovered from hyperglycemia and hypertension after 23 weeks on a diet of whole grains, traditional Chinese medicinal foods and prebiotics.

A decreased abundance of endotoxin biosynthetic genes in the gut of the volunteer was correlated with a decreased circulating endotoxin load and alleviated inflammation. Mono-association of germfree C57BL/6J mice with strain Enterobacter cloacae B29 isolated from the volunteer' s gut induced fully developed obesity and insulin resistance on a high-fat diet but not on normal chow diet, whereas the germfree control mice on a high-fat diet did not exhibit the same disease phenotypes.

The Enterobacter-induced obese mice showed increased serum endotoxin load and aggravated inflammatory conditions. The obesity-inducing capacity of this human-derived endotoxin producer in gnotobiotic mice suggests that it may causatively contribute to the development of obesity in its human host.

Source: Isaude.net
   Palavras-chave:   Obesity    Gut bacteria    Enterobacteria    Endotoxin    Shanghai Jiao Tong University    Zhao Liping   
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Obesity    gut bacteria    enterobacteria    endotoxin    Shanghai Jiao Tong University    Zhao Liping   
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