General
publicado em 14/11/2012 às 15h21:00
   Dê o seu voto:

Study confirms benefit of 3D physical exercise to reverse hypertension

Search USP adopted stereology, science allowing cells by measuring the height, width and depth

 
font size
A-
A+

Some pieces of information on this page may have been automatically translated. Makernews is not responsible for the irregularities resulting from these translations. When in doubt,      consult the original text.



Foto: Divulgação/Antonio Augusto Coppi
Mice on a treadmill during the search process. To treat hypertension, is associated with better physical exercise and pharmacology.
  « Previous
next »  
Mice on a treadmill during the search process. To treat hypertension, is associated with better physical exercise and pharmacology.

In the Faculty of Veterinary Medicine (FMVZ) USP, researchers used 3D microscopy (stereology) to confirm the benefits of exercise to reverse the effects of hypertension on the major arteries of the body.

The stereology is a science that allows measuring cells using statistical and mathematical calculations taking into account spatial height, width and depth (3D), and the fourth dimension, time (4D). The advantage over morphometry (analysis in two dimensions - height and width) is the high accuracy and the fact that estimating the number and total volume of cells (among others). Already morphometry measures only the contours (profiles) of the particles analyzed.

Hypertension causes hypertrophy of the thoracic aorta. There is an increase of collagen and elastic tissue and muscle, making the artery wall thicker. Pharmacological treatment of hypertension reverses the increased collagen and muscle tissue, but can not decrease the content increased elastic walls of the artery. And this is where the role of physical training.

Through stereology, we estimated the volume of the thoracic aorta and its constituents: elastic tissue, muscle and connective tissue. We found that exercise led to the standardization of the content of these tissues, pointing estereologista Antonio Augusto Coppi, head of the Laboratory of Stochastic Stereology and Chemical Anatomy (LSSCA) Department of Surgery FMVZ. The LSSCA is a world reference in quantitative microscopy and 3D active member of the International Society for Stereology (ISS).

For Professor Coppi, who also participated in the survey, the results show the importance of combining drug treatment with low-impact exercise to treat hypertension.

<b> Physical Training </ b>

The experiments were conducted with two groups of mice: normotensive (normal blood pressure) and those born genetically modified to present hypertension. Each of these two groups was further divided into two subgroups: sedentary and trained animals.

The trained group performed physical activity for 3 months, which consisted of low-intensity aerobic exercise (50% to 60% of the total capacity of the exercise), performed on a treadmill for 1 hour per day, 5 days a week.

In humans, this training is equivalent to walking three times per week, five or six speed of the treadmill for 30 to 40 minutes and a workload of 50% to 60%, said teacher.

In all study groups were analyzed with hemodynamic and Polymerase Chain Reaction (PCR), molecular biology technique. The PCR quantifies the RNA expression associated with production of a particular protein such as elastin, which give rise to the stretch fabric, said Professor Coppi. The stereology was applied to view more tangible data obtained by PCR.

<b> Stereology and Molecular Biology </ b>

This is a case where a combination of molecular biology techniques to stereology was vital and very successful. Given that PCR does not evaluate tissue morphology [generates no histological images], we needed images to confirm the normalization of the thoracic aorta and this was made possible by stereology explains.

Source: USP
   Palavras-chave:   Hypertension    Exercise    School of Veterinary Medicine    FMVZ    USP    Universidade de São Paulo   
  • Share this pageShare this page
  • Share this pageCorrect
  • ShareShare
  • AlertAlert
Reduced link: 
  • You are recommending this story: Study confirms benefit of 3D physical exercise to reverse hypertension
  • Fill in the following form to send your recommendation to your friend:

  • You are suggesting a correction for this story: Study confirms benefit of 3D physical exercise to reverse hypertension


Receba notícias do iSaúde no seu e-mail de acordo com os assuntos de seu interesse.
Seu nome:
Seu email:
Desejo receber um alerta com estes assuntos:
hypertension    exercise    School of Veterinary Medicine    FMVZ    USP    Universidade de São Paulo   
Comments:
Comment
Leave your comment
Close
(Required fields are marked with an *)

(Your email address will never be published or shared.)

Enter the letters and numbers below and click in the button "send"

  • Twitter iSaúde
advertising
Informe Saúde printed version

Recommend the portal
Close [X]
  • You are recommending this story: http://www.isaude.net
  • Fill in the following form to send your recommendation to your friend:

RSS news from the portal  iSaúde.net
Get the newsletter of the portal  iSaúde.net
Recommend the portal iSaúde.net
News from  iSaúde.net in your blog or website.
Get news on the subject of your interest.
© 2000-2011 www.isaude.net Todos os direitos reservados.