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Acai is not indicated for treating malnutrition in cancer patients

Search USP investigated effects of fruit in dealing with cachexia, a chronic inflammation that leads to excessive weight loss

 
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Researcher investigated the acai supplementation in cases of excessive weight loss.
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Researcher investigated the acai supplementation in cases of excessive weight loss.

Studies at the Institute of Biomedical Sciences, University of São Paulo (ICB-USP) have helped to clarify aspects associated with cancer, especially in relation to acai supplements to treat malnutrition in patients with the disease. Research shows that supplementation with acai compound can act as anti-inflammatory, but causes a significant increase in tumor mass.

The findings make part of research conducted by associate professor of ICB, Marília Seelaender, which seeks to characterize cachexia associated with cancer, consisting of a chronic inflammation of the organs leading to malnutrition and excessive weight loss. The researcher investigated the acai supplementation in cases of cachexia in his latest scientific work done on the subject.

Cachexia is expressed in 80% of cases terminals and is responsible for the death of more than 20% of cancer patients. Still, it is treated by substituting caloric, which has proved completely ineffective, said Seelaender.

Much more than a calorie diet which, according to her, is the most common recommendation for alleviating cachexia, the research proposed to examine the effect of that food on a diet long term, aiming at the modulation of gene expression by nutrient fruit.

It is known that acai has anti-inflammatory properties in its natural composition. However, studies on the ICB found that in commercial beverages, with the addition of glucose syrup, metabolic nutrient gains are eliminated.

This was verified in the first phase of the project, when tested acai drinks found in supermarkets supplementation in healthy rats. We noted early steatosis or fatty liver, reduction of enzymes related to metabolism of glucose and increased weight and adiposity, said Seelaender.

In the second stage of the research, the glucose syrup was replaced with organic honey, which has antiproliferative properties. This time, we found that in both healthy animals as they carried the tumor, the intake of juice eventually made the anti-inflammatory property of acai openly, said Seelaender.

Increased tumor <b> </ b>

Another property of acai, even more than the known anti-inflammatory, is antioxidant. Seelaender team and tried to ascertain whether supplementation with acai juice and honey resulted in the reduction of oxidative stress-related cachexia.

The ingestion of such a compound decreased the concentration of malondialdehyde which is an element pro-oxidant only in healthy rats. Furthermore, in diseased animals, it caused a significant increase in tumor mass, said.

The result is that although the nutrients açaí bring improvements over the body's inflammatory profile, they are not effective in combating oxidative stress and can still result in tumor growth.

Because of this, do not indicate supplementation with acai for the treatment of cachexia associated with cancer, warned Seelaender, which currently conducts human trials to analyze the effects of physical exercise in combating this symptom.

According to the researcher, this relationship has already been studied in rats with surprising results. All symptoms of cachexia were offset by regular physical activity and, in humans, we have also noticed a decrease in tumor mass, said.

<i> information Fapesp </ i>

Source: Isaude.net
   Palavras-chave:   Acai    Cachexia    Malnutrition    Tumor    USP    University of Birmingham    Institute of Biomedical Sciences    ICB    Marília Seelaender   
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Acai    cachexia    malnutrition    tumor    USP    University of Birmingham    Institute of Biomedical Sciences    ICB    Marília Seelaender   
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