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publicado em 21/10/2012 às 10h30:00
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Portuguese drug test able to treat lung diseases in fetuses

Substance can be used to treat lung abnormalities in babies without causing side effects

 
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Foto: ECS/UM
Cristina Nogueira-Silva, responsible for research
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Cristina Nogueira-Silva, responsible for research

Researchers at the University of Minho in Portugal, tested successfully, a drug capable of correcting malformations related lung growth in fetuses.

These malformations are associated with high mortality rates in neonates. The substance, which has been evaluated in animals, could be administered to pregnant women whose fetuses have similar situations, in order to ensure growth and lung function and increase the survival rate of those involved, with no side effects for the mother or in children.

In their work, the researcher Cristina Nogueira-Silva showed that the drug PD-123319 can be used for the treatment of fetal pulmonary hypoplasia, or underdevelopment of the organ.

"This can solve many problems related to congenital lung diseases. For example, in the case of congenital diaphragmatic hernia (CDH), a hole in the diaphragm that allows the abdominal contents to reach the chest cavity, newborns have severe difficulty breathing after birth, "said Nogueira-Silva.

According to the researchers, despite the immense variety of clinical research and new therapeutic solutions, sophisticated techniques of assisted ventilation and neonatal intensive care units, the mortality rate associated with CDH remains close to 50%.

The team concludes that the research paper, published in the journal PLoS ONE, presents a new therapeutic hope for these infants and their families.

Source: Isaude.net
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Pulmonary disease    fetal lung malformations    PD-123319    University of Minho    Cristina Nogueira-Silva   
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