publicado em 05/10/2012 às 19h20:00
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Nanoparticles release drugs selectively in damaged cells

Approach may be used in treating diseases linked with aging such as Alzheimer's and Parkinson

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Researchers from the Polytechnic University of Valencia, Spain, have developed smart nanoparticles can release therapeutic substances selectively aging in human cells.

Clinical trials show that the approach has the potential to be used in the treatment of cancer and related diseases, Alzheimer or Parkinson.

According to the team, this application can also be useful for the development of cosmetic topical therapies that have anti-wrinkle and anti-aging effect, or increase the protection against UV radiation, and serve to treat baldness.

"For the first time demonstrated that selected substances can be released only in cells that are undergoing degenerative or senescent and not in others," says lead researcher Ramón Martínez Manez.

Senescence is a physiological process of the body to eliminate aged cells or alterations that may impair their viability. "When we are young, the mechanisms of senescence prevent, for example, the appearance of tumors. But with aging, senescent cells accumulate in tissues and organs, changing the correct operation of the same," the authors explain.

The elimination of these cells slows the onset of diseases associated with aging.

The team tested the new nanoparticles in cells of patients with a syndrome known as accelerated aging Dyskeratosis Congenita. The cell cultures showed a high percentage of senescence, characterized by high levels of beta-galactosidase activity, an enzyme characteristic of the senescent state.

"The aged cells expressing this enzyme and excess nanoparticles we designed are opened in her presence, releasing their contents to eliminate senescent cells, prevent their deterioration or even reactivate them for their rejuvenation," explains Manez.

The team concluded that the nanoparticles are a unique opportunity to deliver therapeutic compounds selectively in the affected tissues and rescue the viability and functionality of these

The next step will be to test devices with therapeutic agents and validate them in animal models.

Veja mais detalhes sobre esta pesquisa (em inglês).

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Nanoparticles    Alzheimer's    Parkinson's    cancer    Polytechnic University of Valencia    Ramon Martinez Manez   
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