General
publicado em 04/10/2012 às 10h10:00
   Dê o seu voto:

African snake venom can produce analgesic as effective as morphine

Peptides present in breast black toxic poison can suppress the sensation of pain without causing side effects

 
font size
A-
A+
Foto: Flickriver/Guenter Leiten Bauer
Encontrada na África, a mamba negra possui veneno potente
  « Previous
next »  
Encontrada na África, a mamba negra possui veneno potente

A bite from the black mamba snake (Dendroaspis polylepis) can kill an adult human within 20 minutes. But mixed in with that toxic venom is a new natural class of compound that could be used to help develop new painkillers.

Named " mambalgins," these peptides block acute and inflammatory pain in mice as well as morphine does, according to a new study.

Researchers, led by Sylvie Diochot, of the Institute of Molecular and Cellular Pharmacology at Nice University, Sophia Antipolis in France, purified the peptides from the venom and profiled the compounds' structure. They then were able to test the mambalgins in strains of mice with various genetic tweaks to their pain pathways. Diochot and her colleagues determined that the mambalgins work by blocking an as-yet untargeted set of neurological ion channels associated with pain signals. The findings were published online October 3 in Nature (Scientific American is part of Nature Publishing Group).

As a bonus, mambalgins did not have the risky side effect of respiratory depression that morphine does. And the mice developed less tolerance to them over time than is typical with morphine.

Experimenting with the newfound compounds should also help researchers learn more about the mechanisms that drive pain. As the researchers noted in their paper, " It is essential to understand pain better to develop new analgesics. The black mamba peptides discovered here have the potential to address both of these aims."

Venoms from plenty of other species of animals, including spiders, scorpions, ants and even snails, have also been studied for their analgesic potential.

Just don' t try extracting any of this venom in the wild. There is antivenom for the black mamba snake' s bite, but it is not always available, and without it, the bites are usually fatal. These snakes can move along at speeds up to about 20 kilometers per hour and grow to up to 4.4 meters in length.

Source: Isaude.net
   Palavras-chave:   Poison    Analgesic    Black mamba    Mambalgines    Morphine    University of Nice    Sylvie Diochot   
  • Share this pageShare this page
  • Share this pageCorrect
  • ShareShare
  • AlertAlert
Reduced link: 
  • You are recommending this story: African snake venom can produce analgesic as effective as morphine
  • Fill in the following form to send your recommendation to your friend:

  • You are suggesting a correction for this story: African snake venom can produce analgesic as effective as morphine


Receba notícias do iSaúde no seu e-mail de acordo com os assuntos de seu interesse.
Seu nome:
Seu email:
Desejo receber um alerta com estes assuntos:
Poison    analgesic    black mamba    mambalgines    morphine    University of Nice    Sylvie Diochot   
Comments:
Comment
Leave your comment
Close
(Required fields are marked with an *)

(Your email address will never be published or shared.)

Enter the letters and numbers below and click in the button "send"

  • Twitter iSaúde
advertising
Informe Saúde printed version

Recommend the portal
Close [X]
  • You are recommending this story: http://www.isaude.net
  • Fill in the following form to send your recommendation to your friend:

RSS news from the portal  iSaúde.net
Get the newsletter of the portal  iSaúde.net
Recommend the portal iSaúde.net
News from  iSaúde.net in your blog or website.
Get news on the subject of your interest.
© 2000-2011 www.isaude.net Todos os direitos reservados.