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publicado em 26/09/2012 às 14h46:00
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Study points Unicamp relationship between obesity and colon cancer

Research of the State University of Campinas chronic inflammation correlates with the development of colorectal tumors

 
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Foto: Antonio Scarpinetti/Ascom/Unicamp
Foto: Antonio Scarpinetti/Ascom/Unicamp
Professor Jose Barreto Campelo Carvalheira, thesis advisor Researcher Marcelo Benedito da Silva Flores, author of the study
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Professor Jose Barreto Campelo Carvalheira, thesis advisor
Researcher Marcelo Benedito da Silva Flores, author of the study

Study conducted at the State University of Campinas (Unicamp) describes the unprecedented step an important mechanism linking obesity to the development of colon cancer. The research chronic inflammation correlates with the development of colorectal tumors. The paper describing the research was featured in the September issue of the journal Gastroenterology.

According to Professor Jose Barreto Campello Unicamp Carvalheira, guiding in the study, the link between obesity and several types of cancer is very recent. Obese people are prone to almost all types of the disease, and particularly in relation to colorectal cancer, only in the year 2012 were reported by The American Cancer Society approximately 103 000 new cases of the disease, with 51 000 deaths related to it in USA. Obesity increases the incidence of colorectal cancer, as well as leading to their recurrence and higher mortality due to the disease. The pioneering spirit of our work is to correlate the chronic inflammation that occurs in obesity, with the development of colorectal tumors: this is a major breakthrough, says.

At work started five years ago, we list as possible mediators of this relation the high insulin concentrations, observed in our models of obesity as well as chronic inflammation changes imposed by the adipose tissue of animals against obesity, says the professor.

Five years of research because of difficulties getting to experimental models for this type of cancer. After this phase, the results were surprising, "explains Marcelo Flores, first author of the article and the author's doctoral thesis. Marcelo was responsible for the preparation and execution of animal experiments in the laboratory workbench Molecular Cancer Research, Faculty of Medical Sciences Unicamp (FCM).

Also according to him, these data are very important because they prove the physiological and molecular links between obesity and colon cancer.

Source: Isaude.net
   Palavras-chave:   Obesity    Colon cancer    Unicamp    Campinas State University    Jose Barreto Campello Carvalheira   
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