publicado em 25/09/2012 às 21h56:00
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Researchers test vaccine against lung disease caused by fungus

Fungi may also affect skin, mouth, larynx, liver, and infiltrating the bone and central nervous system

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Researchers from the Faculty of Pharmaceutical Sciences, University of São Paulo (USP-FCF) have tested a new vaccination strategy against a disease little known but potentially crippling: paracoccidioidomycosis.

Caused by the fungus Paracoccidioides brasiliensis, common in rural areas, the disease causes a chronic inflammatory process that leads to the formation of fibrosis in the affected tissues.

As the main form of transmission is by inhalation, the sequel is the most common chronic obstructive pulmonary disease. But the fungus can also affect skin, mouth, larynx, liver and spleen, and infiltrating the bone, joints and central nervous system.

According to the researcher responsible for the study, Silvana Suelen dos Santos, existing treatments are time consuming, often requiring hospitalization of the patient and cause significant side effects. So bet on a therapeutic vaccine capable of stimulating the immune system to fight the disease. But we are also testing the vaccine in a prophylactic protocol, to see if she is able to prevent infection, he says.

It is estimated that there are 10 million infected with Paracoccidioides brasiliensis in Latin America focused on Brazil, Argentina, Venezuela and Colombia. Of these, only 2% develop the disease, a fact often associated with food shortages, alcoholism, smoking or preexisting conditions.

Although we do not have the results of the treatment protocol. The animals have been infected, but as the disease develops slowly, the work will take longer to complete, said Santos.

<i> information Fapesp </ i>

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paracoccidioidomycosis    vaccine    lung disease    Faculty of Pharmaceutical Sciences    University of São Paulo    USP    Universidade de São Paulo   
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