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publicado em 20/09/2012 às 18h30:00
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Exposure to pollution during pregnancy cause vitamin D deficiency in babies

New research suggests that air pollution can lead to the development of disease in these children later in life

 
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Poluição do ar pode causar deficiência de vitamina em recém-nascidos
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Poluição do ar pode causar deficiência de vitamina em recém-nascidos

Vitamin D deficiency has been implicated in the increased risk of several diseases. Exposure to air pollution has been suggested as a contributor to vitamin D deficiency. However, studies that have examined the effects of air pollution on vitamin D status are few and have never focused on prenatal life as an exposure window.

Our aim was to investigate the associations between gestational exposure to urban air pollutants and 25-hydroxyvitamin D [25(OH)D] cord blood serum level in 375 mother-child pairs of the EDEN birth cohort.

The Atmospheric Dispersion Modelling System (ADMS-Urban) pollution model, a validated dispersion model combining data on traffic conditions, topography, meteorology, and background pollution, was used to assess the concentrations of two major urban pollutants, particulate matter less than 10 ìm in diameter (PM10) and nitrogen dioxide (NO2), at the mother's home address during pregnancy. Cord blood samples were collected at birth and were analyzed for levels of 25(OH)D.

Maternal exposure to ambient urban levels of NO2 and PM10 during the whole pregnancy was a strong predictor of low vitamin D status in newborns. After adjustment, log-transformed 25(OH)D decreased by 0.15 U (P = 0.05) and 0.41 U (P = 0.04) for a 10-ìg/m3 increase in NO2 and PM10 pregnancy levels, respectively. The association was strongest for third-trimester exposures (P = 0.0003 and P = 0.004 for NO2 and PM10, respectively).

Gestational exposure to ambient urban air pollution, especially during late pregnancy, may contribute to lower vitamin D levels in offspring. This could affect the child's risk of developing diseases later in life.

Source: Isaude.net
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Pollution    vitamin D    pregnancy    Intitut National de la Santé et de la Recherche Médicale    Nour Baïz   
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