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publicado em 09/05/2013 às 14h21:00
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Difficulty waking up early is not just a matter of laziness

Researchers point to SP combination of genetic and environmental factors, including the geographical location in which they live

 
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Research conducted at the Sleep Institute (CEPID-FAPESP) reveal that people living near the equator tend to sleep earlier and wake
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Research conducted at the Sleep Institute (CEPID-FAPESP) reveal that people living near the equator tend to sleep earlier and wake

Studies in Sleep Institute, in São Paulo, show that the difficulty in waking up early that some people have can not be simply a matter of laziness, but result from a combination of genetic and environmental factors, including the geographical location in which they lives.

People who live near the equator are more likely to morningness, ie preference for sleeping and waking up early. As we approach the poles, individuals become more evening, informs Mario Pedrazzoli, professor at the School of Arts, Sciences and Humanities, University of São Paulo (USP). The hypothesis that latitude would be one of the regulatory elements of the cycle of sleep and wakefulness was lifted in 2005, told Pedrazzoli. A equipe havia acabado de publicar na revista Sleep resultados de uma pesquisa financiada pela FAPESP que mostrava associação entre uma determinada variação no gene PER3 e a síndrome da fase atrasada do sono.

People with this disorder feel sleep much later than the average population, around four or five o'clock in the morning. This can be a problem for those who need to wake up early, said Pedrazzoli.

"People with this disorder feel sleep much later than the average population, around four or five o'clock in the morning. This can be a problem for those who need to wake up early"

Based on studies of samples, the researchers calculated that the allelic variation in homozygous gene PER3 associated with sleep disturbance is present in about 10% of individuals, but only a small portion of this group develops the syndrome.

This suggests that part of the problem arises from the gene and part of the environment. Then came the suspicion that the geographical position in which the person lives could influence the regulation of sleep, said Pedrazzoli.

Tests <b> </ b>

The researchers interviewed 16,000 people from all Brazilian states through a questionnaire that was available on the Internet between 2005 and 2007. Data showed that although the sun rises about the same time in Natal and Porto Alegre during the summer, the sunset occurs later in the South, encouraging locals to stay awake longer.

In the winter, the sun sets almost at the same time in the North and South, but born earlier in Natal than in Porto Alegre, encouraging potiguares sleep and waking up earlier than the Gauchos.

<b> Preventive Medicine </ b>

Now we are working with transgenic animals. The idea is to insert this piece of the gene exists only in primates in laboratory mice and mimic the variation of short days and long to better understand the interaction between sleep and behavior PER3, told Pedrazzoli.

This knowledge, assessed, may be useful in preventive medicine. If we can identify a genotype more likely to suffer from sleep disorders, the doctor may advise that person to change habits or avoid activities that may favor the disease, how to work at night, for example, said.

<i> information Fapesp </ i>

Source: Isaude.net
   Palavras-chave:   Preguisa    Sleep    Difficulty waking    Sleep medicine    Sleep Institute    Sao Paulo   
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