General
publicado em 12/09/2012 às 10h01:00
   Dê o seu voto:

Scientists from United Kingdom discover mechanism of aging neurons

Research will improve understanding of diseases linked to nerve cells in the brain, such as dementia and Parkinson

 
font size
A-
A+

Researchers at Newcastle University have revealed the mechanism by which neurons, the nerve cells in the brain and other parts of the body, age.

The research, published today in Aging Cell, opens up new avenues of understanding for conditions where the ageing of neurons are known to be responsible, such as dementia and Parkinson' s disease.

The ageing process has its roots deep within the cells and molecules that make up our bodies. Experts have previously identified the molecular pathway that react to cell damage and stems the cell' s ability to divide, known as cell senescence.

However, in cells that do not have this ability to divide, such as neurons in the brain and elsewhere, little was understood of the ageing process. Now a team of scientists at Newcastle University, led by Professor Thomas von Zglinicki have shown that these cells follow the same pathway.

This challenges previous assumptions on cell senescence and opens new areas to explore in terms of treatments for conditions such as dementia, motor neuron disease or age-related hearing loss.

Newcastle University' s Professor Thomas von Zglinicki (pictured above) who led the research said: " We want to continue our work looking at the pathways in human brains as this study provides us with a new concept as to how damage can spread from the first affected area to the whole brain."

Working with the University' s special colony of aged mice, the scientists have discovered that ageing in neurons follows exactly the same rules as in senescing fibroblasts, the cells which divide in the skin to repair wounds.

DNA damage responses essentially re-program senescent fibroblasts to produce and secrete a host of dangerous substances including oxygen free radicals or reactive oxygen species (ROS) and pro-inflammatory signalling molecules. This makes senescent cells the ' rotten apple in a basket' that can damage and spoil the intact cells in their neighbourhood. However, so far it was always thought that ageing in cells that can' t divide - post-mitotic, non-proliferating cells - like neurons would follow a completely different pathway.

Now, this research explains that in fact ageing in neurons follows exactly the same rules as in senescing fibroblasts.

Professor von Zglinicki, professor of Cellular Gerontology at Newcastle University said: " We will now need to find out whether the same mechanisms we detected in mouse brains are also associated with brain ageing and cognitive loss in humans. We might have opened up a short-cut towards understanding brain ageing, should that be the case."

Dr Diana Jurk, who did most of this work during her PhD in the von Zglinicki group, said: " It was absolutely fascinating to see how ageing processes that we always thought of as completely separate turned out to be identical. Suddenly so much disparate knowledge came together and made sense."

The research contributes to the Newcastle Initiative on Changing Age, the University' s response to the societal challenge of Ageing, seeking new ways to make the most of the extensive opportunities associated with increasing human longevity.

The team want to further study the mechanism using the unique resource of the Newcastle Brain Bank.

Source: Isaude.net
   Palavras-chave:   Neurons    Aging    Dementia    Parkinson    University of Newcastle    Thomas von Zglinicki   
  • Share this pageShare this page
  • Share this pageCorrect
  • ShareShare
  • AlertAlert
Reduced link: 
  • You are recommending this story: Scientists from United Kingdom discover mechanism of aging neurons
  • Fill in the following form to send your recommendation to your friend:

  • You are suggesting a correction for this story: Scientists from United Kingdom discover mechanism of aging neurons


Receba notícias do iSaúde no seu e-mail de acordo com os assuntos de seu interesse.
Seu nome:
Seu email:
Desejo receber um alerta com estes assuntos:
Neurons    aging    dementia    Parkinson    University of Newcastle    Thomas von Zglinicki   
Comments:
Comment
Leave your comment
Close
(Required fields are marked with an *)

(Your email address will never be published or shared.)

Enter the letters and numbers below and click in the button "send"

  • Twitter iSaúde
advertising
Informe Saúde printed version

Recommend the portal
Close [X]
  • You are recommending this story: http://www.isaude.net
  • Fill in the following form to send your recommendation to your friend:

RSS news from the portal  iSaúde.net
Get the newsletter of the portal  iSaúde.net
Recommend the portal iSaúde.net
News from  iSaúde.net in your blog or website.
Get news on the subject of your interest.
© 2000-2011 www.isaude.net Todos os direitos reservados.