Science and Technology
publicado em 07/09/2012 às 11h10:00
   Dê o seu voto:

Chip built into the body monitors glucose level of diabetic patients

Tiny sensor can measure glucose by sweat or tears, and can be used for weeks or months, say researchers

 
font size
A-
A+
Foto: Fraunhofer IMS
Biossensor (abaixo do olho) permite aos pacientes com diabetes medir seus níveis de glicose com o fluido das lágrimas de seus olhos
  « Previous
next »  
Biossensor (abaixo do olho) permite aos pacientes com diabetes medir seus níveis de glicose com o fluido das lágrimas de seus olhos

Pricking a finger everyday is just part of everyday life for many diabetes patients. A non-invasive measurement approach could release them from the constant pain of pin pricks. The linchpin is a biosensor engineered by Fraunhofer researchers: A tiny chip combines measurement and digital analysis and can be radioed to a mobile device.

Sticking yourself in the finger day after day: For many diabetics, this means of checking blood glucose is an everyday part of life. Especially for patients with Type-1 diabetes, who always have to keep a close eye on their levels, since their bodies are incapable of producing the insulin to break down the glucose in the blood. Several times a day, they have to place a tiny drop of blood on a test strip. It is the only way they can ascertain the blood glucose value, so they can inject the correct amount of insulin needed. And this pricking is not only a burdensome: it may also cause inflammation or cornification of the skin. And for pain-sensitive patients, the procedure is agony.

The daily sticking of the finger may soon become a thing of the past, thanks to a diagnostic system with Fraunhofer technology built-in. The underlying concept is a biosensor that is located on the patient' s body. It is also able to measure glucose levels continuously using tissue fluids other than blood, such as in sweat or tears. The patient could dispense with the constant needle pricks. In the past, such bioelectric sensors were too big, too imprecise and consumed too much power. Researchers at the Fraunhofer Institute for Microelectronic Circuits and Systems IMS in Duisburg have recently achieved a major breakthrough: They have developed a biosensor in nano-form that circumvents these hurdles.

Diagnostic system in miniature

The principle of measurement involves an electrochemical reaction that is activated with the aid of an enzyme. Glucose oxidase converts glucose into hydrogen peroxide (H2O2) and other chemicals whose concentration can be measured with a potentiostat. This measurement is used for calculating the glucose level. The special feature of this biosensor: the chip, measuring just 0.5 x 2.0 millimeters, can fit more than just the nanopotentiostat itself. Indeed, Fraunhofer researchers have attached the entire diagnostic system to it. " It even has an integrated analog digital converter that converts the electrochemical signals into digital data," explains Tom Zimmermann, business unit manager at IMS. The biosensor transmits the data via a wireless interface, for example to a mobile receiver. Thus, the patient can keep a steady eye on his or her glucose level. " In the past, you used to need a circuit board the size of a half-sheet of paper," says Zimmermann. " And you also had to have a driver. But even these things are no longer necessary with our new sensor."

Durable biosensor

The minimal size is not the only thing that provides a substantial advantage over previous biosensors of this type. In addition, the sensor consumes substantially less power. Earlier systems required about 500 microamperes at five volts; now, it is less than 100 microamperes. That increases the durability of the system allowing the patient to wear the sensor for weeks, or even months. The use of a passive system makes this durability possible. The sensor is able to send and receive data packages, but it can also be supplied with power through radio frequency.

The glucose sensor was engineered by the researchers at Noviosens, a Dutch medical technology firm. Since it can be manufactured so cost-effectively, it is best suited for mass production. These non-invasive measuring devices for monitoring blood glucose levels may become the basis for a particularly useful further development in the future: The biochip could control an implanted miniature pump that, based on the glucose value measured, indicates the precise amount of insulin to administer. That way, diabetes patients could say goodbye to incessant needle-pricks forever.

Source: Isaude.net
   Palavras-chave:   Glucose    Diabetes    Chip    Biosensor    Fraunhofer Institute    Tom Zimmermann   
  • Share this pageShare this page
  • Share this pageCorrect
  • ShareShare
  • AlertAlert
Reduced link: 
  • You are recommending this story: Chip built into the body monitors glucose level of diabetic patients
  • Fill in the following form to send your recommendation to your friend:

  • You are suggesting a correction for this story: Chip built into the body monitors glucose level of diabetic patients


Receba notícias do iSaúde no seu e-mail de acordo com os assuntos de seu interesse.
Seu nome:
Seu email:
Desejo receber um alerta com estes assuntos:
Glucose    diabetes    chip    biosensor    Fraunhofer Institute    Tom Zimmermann   
Comments:
Comment
Leave your comment
Close
(Required fields are marked with an *)

(Your email address will never be published or shared.)

Enter the letters and numbers below and click in the button "send"

  • Twitter iSaúde
advertising
Informe Saúde printed version

Recommend the portal
Close [X]
  • You are recommending this story: http://www.isaude.net
  • Fill in the following form to send your recommendation to your friend:

RSS news from the portal  iSaúde.net
Get the newsletter of the portal  iSaúde.net
Recommend the portal iSaúde.net
News from  iSaúde.net in your blog or website.
Get news on the subject of your interest.
© 2000-2011 www.isaude.net Todos os direitos reservados.