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publicado em 26/08/2012 às 09h00:00
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Medicine has the potential to combat tuberculosis and bladder cancer

It is the first time that the possible common mechanisms of action of the drug against the two diseases are described

 
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Foto: Antoninho Perri/Ascom/Unicamp
Foto: Antoninho Perri/Ascom/Unicamp
Professor Joseph Wagner Fávaro (the left)., Iseu Nunes, business administrator (center) and researcher Fabio Sap. P-Map drug may be useful in combating tuberculosis and bladder cancer.
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Professor Joseph Wagner Fávaro (the left)., Iseu Nunes, business administrator (center) and researcher Fabio Sap.
P-Map drug may be useful in combating tuberculosis and bladder cancer.

Unicamp researchers are developing a drug that may be useful in combating tuberculosis and bladder cancer. The work shows that the P-Map, a type of medicine, is capable of activating certain receptors of the immune system and promote disease in experimental animals. It is the first time that the possible common mechanisms of action of the drug against the two diseases are described.

The P-map is being tested for a long time and already knew he could act against cancer in animals. A pleasant surprise in recent years was the demonstration of its effect also on infectious diseases in vivo [in laboratory animals], like malaria, listeriosis and visceral leishmaniasis in dogs. Our researchers were initially perplexed because they could not see a common point for understanding the role in pathologies as diverse recalls the business administrator Iseu Nunes, son of idealistic medical treatment, Odilon da Silva Nunes (1922-2001), who for more than 60 years in a laboratory maintained at his own expense, researching products originated from fungi with potential antitumor. In 2001, Durán and created a Nunes Farmabrasilis, a research network and open nonprofit that, among other products, developed and made available for free a derivative of the original molecule created by Odilon Nunes, the P-map for research aimed at treating neglected diseases and public health applications.

"If this effect persists in humans, we may have taken a big step to put a potent drug in clinical use"

Professor Joseph Wagner Fávaro, the Institute of Biology (IB) at UNICAMP, explains that the new research on the mechanisms of action allow you to view at least one common pathway: the role of toll-like receptors that are warning of cells, both for infectious diseases and for some types of cancer. As an additional result, we have confirmed through studies performed in Brazil and the United States that the P-Map can act on cancer and infectious diseases.

Researchers believe Farmabrasilis of the P-map one of the most versatile developing immunomodulators, for combining a broad spectrum of activity with low adverse side effects at the dosages used in experimental animals. The product has already been tested in rats, mice, monkeys, dogs, small and large doses, and in these species revealed no significant toxicity or that forced the withdrawal of the medication. If this effect persists in humans, we may have taken a big step to put a potent drug in clinical use, precisely because of this combination: broad spectrum of activity with low adverse side effect, says Nunes Iseu, with the caveat that this still relies confirmation future.

<b> The P-map </ b>

P-Map is the abbreviation for added polymer-palmitoleate fosfolinoleato magnesium and ammonium protein, the product from the fungus Aspergillus oryzae. According to the investigators, the product is a biological response modifier, ie modifies the response of the organism against diseases and may also act differently on different diseases. An example of a biological response modifier used is well known and Interferon, illustrates Iseu Nunes, one of the coordinators of Farmabrasilis network, which brings together dozens of researchers working on projects involving the P-map around the world.

<i> information Unicamp </ i>

Source: Isaude.net
   Palavras-chave:   Tuberculosis    Bladder cancer    Drug    P-Map    Unicamp    Campinas University   
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