General
publicado em 20/08/2012 às 15h58:00
   Dê o seu voto:

Genes carried by E.coli bacteria increases risk of colon cancer

Research suggests that bacteria have greater involvement in the progression of colon cancer than previously thought

 
font size
A-
A+

Scientists at the University of Liverpool have identified a type of E.coli bacteria that may encourage the development of colon cancer.

The Liverpool team had previously shown that people with colon cancer and with the inflammatory bowel diseases, Crohn' s disease and ulcerative colitis, have high numbers of a sticky type of E.coli in their colons.

The team have now found that E.coli bacteria, which carry pks genes that encode a toxin that damages DNA in the cells of the gut lining, are more commonly found in the colons of patients that have inflammatory bowel disease and colon cancer than those that do not have these conditions. Approximately two thirds of patients with colon cancer carry these E. coli compared with one in five with a healthy colon.

Research, in collaboration with the University of North Carolina, showed that mice with colitis are more likely to carry these E. coli and they often develop colon cancer when carrying E. coli containing pks genes. They did not, however, develop cancer with identical E. coli that did not contain pks. They also found that the presence of E. coli carrying the pks genes did not appear to increase inflammation of the gut.

Professor Jonathan Rhodes, from the University' s Institute of Translational Medicine, said: " The fact that the pks-positive E. coli seemed to promote colon cancer in mice without causing increased inflammation led us to investigate its possible role in human colon cancer.

" The marked increase in the presence of these bacteria in the colon, not only in patients with inflammatory bowel disease, but also in patients with colon cancer who do not have inflammatory bowel disease, suggests that damage caused to DNA, as a result of the toxin that the pks genes produce, may promote the development of colon cancer."

Dr Barry Campbell, co-author of the research at the University of Liverpool, said: " The research suggests that E. Coli has a much wider involvement in the development of colon cancer than previously thought. It is important to build on these findings to understand why this type of bacteria, containing the pks genes, is present in some people and not others."

Source: Isaude.net
   Palavras-chave:   Colon cancer    Bacterium E. coli    PKS genes    University of Liverpool    Jonathan Rhodes   
  • Share this pageShare this page
  • Share this pageCorrect
  • ShareShare
  • AlertAlert
Reduced link: 
  • You are recommending this story: Genes carried by E.coli bacteria increases risk of colon cancer
  • Fill in the following form to send your recommendation to your friend:

  • You are suggesting a correction for this story: Genes carried by E.coli bacteria increases risk of colon cancer


Receba notícias do iSaúde no seu e-mail de acordo com os assuntos de seu interesse.
Seu nome:
Seu email:
Desejo receber um alerta com estes assuntos:
Colon cancer    bacterium E. coli    PKS genes    University of Liverpool    Jonathan Rhodes   
Comments:
Comment
Leave your comment
Close
(Required fields are marked with an *)

(Your email address will never be published or shared.)

Enter the letters and numbers below and click in the button "send"

  • Twitter iSaúde
advertising
Informe Saúde printed version

Recommend the portal
Close [X]
  • You are recommending this story: http://www.isaude.net
  • Fill in the following form to send your recommendation to your friend:

RSS news from the portal  iSaúde.net
Get the newsletter of the portal  iSaúde.net
Recommend the portal iSaúde.net
News from  iSaúde.net in your blog or website.
Get news on the subject of your interest.
© 2000-2011 www.isaude.net Todos os direitos reservados.