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publicado em 04/11/2009 às 10h30:00
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New mouthwash USP incorporates action of rosemary-of-field

Product has already been approved in clinical trials that showed its effectiveness in controlling the bacterial biofilm

 
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The anti-microbial properties of rosemary-of-field are present in a new mouthwash developed at the Faculty of Pharmaceutical Sciences of Ribeirão Preto (FCFRP), USP. The product, currently under patent application has already been approved in clinical trials that showed its effectiveness in controlling the bacterial biofilm, helping to prevent cavities.

The base product is the extract and essential oil of leaves of the plant Baccharis dracunculifolia, better known as Rosemary or field-broom. It was known anti-microbial activity of the extract compared to cariogenic factors of Streptococcus mutans, one of the main microorganisms responsible for the formation of cavities, says the pharmacist responsible for the research, Matthew Leite Freire. The aim was to develop a formulation of mouthwash that could convey the statement.

At work, it was found that rosemary extract field-was slightly soluble in water, preventing thus obtaining a simple aqueous solution. Therefore, we developed a microemulsion system, in which the oil and extract were dispersed in aqueous medium and stabilized with a mixture of surfactant and co-surfactant, generating particles a few nanometers in diameter.

Germany

Efficiency

The extract and oil are linked to sodium fluoride, a substance used as a source of fluoride ions with preventive action in the formation of dental caries, and other components, for obtaining the mouthwash. The tests showed good antimicrobial activity and low toxicity, says Leite. This product is devoid of staining properties of the teeth was considered clinically acceptable.

The doctoral research of the pharmacist had the guidance of Professor Augusto César Cropanese Spadaro, the FCFRP. The research group had already certified teacher in a previous study, the anti-cariogenic activity of rosemary extract-of-field, comparing it with the anti-microbial qualities of green propolis, since it is a Baccharis dracunculifolia of the main botanical sources of green propolis produced in Southeastern Brazil, says the researcher.

The formulation has also undergone clinical trials at the Faculty of Dentistry of Ribeirão Preto (FORP), USP, which was evaluated in humans and compared with two other brands of mouthwash on the market. The product is efficient, he says. It has a greenish color, chlorophyll, and the aroma reminds of rosemary. Clinical tests were conducted by the research group of Professor Vinicius Pedrazzi, the FORP.

According to the pharmacist, the product has had a patent pending with the National Institute of Industrial Property (INPI). It is a technology that is able to be transferred to any company interested in putting the product on the market stresses.

Source: USP
   Palavras-chave:   Mouthwash    Rosemary-of-field    Baccharis dracunculifolia    USP    FCFRP      
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