Science and Technology
publicado em 27/07/2012 às 10h29:00
   Dê o seu voto:

Alcohol could intensify the effects of some drugs in the body

Alcohol made several medications up to three times more available to the body, effectively tripling the original dose

 
font size
A-
A+

Scientists are reporting another reason - besides possible liver damage, stomach bleeding and other side effects - to avoid drinking alcohol while taking certain medicines. Their report in ACS' journal Molecular Pharmaceutics describes laboratory experiments in which alcohol made several medications up to three times more available to the body, effectively tripling the original dose.

Christel Bergström and colleagues explain that beverage alcohol, or ethanol, can cause an increase in the amount of non-prescription and prescription drugs that are "available" to the body after taking a specific dose. Alcohol can change how enzymes and other substances in the body interact with many of the 5,000 such medications on the market. Some of these medications don't dissolve well in the gastrointestinal tract - especially in the stomach and intestines. The researchers sought to test whether ethanol made these drugs dissolve more easily. If so, this would make the drugs more available in the body, possibly intensifying their effects when combined with alcohol.

To find out, the scientists used a simulated environment of the small intestine to test how rapidly medications dissolved when alcohol was and was not present. Almost 60 percent of the 22 medications in their tests dissolved much faster in the presence of alcohol. In addition, they found that certain types of substances, such as those that were acidic, were more affected. Some common acidic drugs include warfarin, the anticoagulant; Tamoxifen, used to treat certain forms of cancer; and naproxen, which relieves pain and inflammation.

Source: Isaude.net
   Palavras-chave:   Drug    Effects    Drug effect    Alcohol    Medication   
  • Share this pageShare this page
  • Share this pageCorrect
  • ShareShare
  • AlertAlert
Reduced link: 
  • You are recommending this story: Alcohol could intensify the effects of some drugs in the body
  • Fill in the following form to send your recommendation to your friend:

  • You are suggesting a correction for this story: Alcohol could intensify the effects of some drugs in the body


Receba notícias do iSaúde no seu e-mail de acordo com os assuntos de seu interesse.
Seu nome:
Seu email:
Desejo receber um alerta com estes assuntos:
drug    effects    Drug effect    Alcohol    medication   
Comments:
Comment
Manuel Mourã
posted on:
17/12/2012 22:19:56
existe algum estudo dos efeitos do alcool na pessoa a fazer Tamoxifene?
maria gorete
posted on:
21/10/2010 13:12:22
eu uso a 6 anos rivotril 2 mg e tomo frequente cerveja e a noite tmo rivotril isso pode compilicar o meu organisno o q pode acontecer obrigado espero resposta ok
Leave your comment
Close
(Required fields are marked with an *)

(Your email address will never be published or shared.)

Enter the letters and numbers below and click in the button "send"

  • Twitter iSaúde
advertising
Informe Saúde printed version

Recommend the portal
Close [X]
  • You are recommending this story: http://www.isaude.net
  • Fill in the following form to send your recommendation to your friend:

RSS news from the portal  iSaúde.net
Get the newsletter of the portal  iSaúde.net
Recommend the portal iSaúde.net
News from  iSaúde.net in your blog or website.
Get news on the subject of your interest.
© 2000-2011 www.isaude.net Todos os direitos reservados.