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publicado em 26/07/2012 às 21h52:00
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Research seeks to mitigate the effects of anesthetics used after surgery

Although the body's response to medication is expected, release of inflammatory substances may lead to thrombosis

 
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Study conducted at the Faculty of Medicine, Universidade Estadual Paulista (UNESP) investigates the effect of two commonly used inhaled anesthetics isoflurane and sevoflurane triggered inflammatory reaction in the body after surgery.

The investigation was conducted in rats subjected to a procedure for the removal of a kidney and revealed that the drug isoflurane caused a greater release of inflammatory substances evaluated.

When you go through a surgery, the body realizes that he is suffering an assault calls and releases inflammatory cytokines. They activate blood clotting and help prevent bleeding.

Norma Sue Modolo Pinheiro, FM teacher and coordinator of research, this reaction is expected but can not be overstated because of the risk of thrombosis.

The research tries to find an anesthetic that can modulate the inflammatory response. It can not be canceled because the patient would suffer bleeding. But it can not be much exacerbated by the drug. This is especially important in high-risk patients, such as heart disease.

The researcher points out, however, that research was done in healthy animals. She believes that a healthy patient undergoing a relatively simple surgery would have no problems with any of the two anesthetics. But in obese people who already have more inflammatory substances in the body, or heart disease, lung disease and newborns, perhaps these anesthetics can cause an exacerbated inflammatory response.

The team intends to follow this line of research, first assessing the effect of drugs in rats with health problems and in the future, in humans. Also we will investigate the action of other anesthetics, including intravenous.

Source: Isaude.net
   Palavras-chave:   Anesthesia    Surgery    Pharmacy    Isoflurane    Inflammation    Bleeding    Universidade Estadual Paulista    UNESP   
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anesthesia    surgery    pharmacy    isoflurane    inflammation    bleeding    Universidade Estadual Paulista    UNESP   
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