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publicado em 25/07/2012 às 10h33:00
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Research presented at the meeting of the SBPC target points for combating leishmaniasis

The discovery contribute to the creation of a new drug which prevents the parasite from infected humans and proliferate in

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A study by researchers at the Department of Physiology, Institute of Biosciences (IB), University of São Paulo (USP), in partnership with scientists at the Department of Molecular Microbiology, School of Medicine, University of Washington, United States, can contribute to development of a new drug which prevents the parasite causes leishmaniasis to infect and proliferate in humans.

In recent years, the group of researchers from USP has been devoted to understanding how the parasite that causes leishmaniasis is related to the man and what materials you use to ensure their survival by infecting a host.

One such material identified by researchers from different countries studying the disease is arginase (an enzyme of the pathway Leishmanias which is essential for parasite growth and is compartmentalized into your glicossoma).

In the research has been demonstrated that the proper compartmentalization of arginase of Leishmania amazonensis in glicossoma is important for the activity and to allow the parasite to infect the host.

We demonstrate that the location of arginase is important in the cellular physiology of the parasite, said Lucile Maria Floeter-Winter, professor and coordinator of the IB project.

According Floeter-Winter, the findings of the study allow for the possibility to interfere with the cycle of the disease, using a new medicament which can inhibit the enzyme of the parasite, for example, in order to stop infection.

. The most important finding of this study was to determine the importance of the location of arginase which is an important target for preventing the parasite grows in mammals. Winter Floeter-evaluated. Because this enzyme is compartmentalized within the glicossoma, the parasite into the amastigote form of fagolissomo (lysosome that performs phagocytosis) and within the macrophage, a new drug or drug for leishmaniasis should do all this journey to inhibit arginase: cross the membrane of the macrophage , the phagosome, the parasite and glicossoma. And this is a hard way, the researcher evaluated.

The results of the research, supported by FAPESP, were published in the journal PLoS One and presented at a conference of the 64th Annual Meeting of the Society for the Advancement of Science (SBPC).

Veja o abstract do estudo

Neglected Disease

Currently the disease is treated with the use of pentavalent antimonials, treatment considered expensive, toxic and ineffective in combating the protozoan Leishmania.

Leishmaniasis is considered by the World Health Organization (WHO) calls one of the neglected diseases, to reach the poor in developing countries and, therefore, does not receive due attention from the pharmaceutical industry to research new drugs.

With information from the Agency FAPESP

   Palavras-chave:   Leishmaniasis    Parasites    Arginase    Leishmania    Lucile Maria Floeter-Winter    64th Annual Meeting of the SBPC      
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