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publicado em 16/07/2012 às 18h16:00
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Helper cells of the blood may be responsible for the removal of hepatitis A

Unlike previously thought, helper cells fight the virus and are in the body until the disease is eliminated

 
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A study by the Nationwide Children's Hospital, in US, indicates that a type of lymphocyte, traditionally known as sidekick of white blood cells, can be effective in fighting infection with hepatitis A. The findings were published in the Journal of Experimental Medicine.

Research has shown that cells known as CD8 + killer T lymphocytes play a critical role in the control of hepatitis C virus infections and hepatitis B. They act by killing the infected liver cells, a process that damages the body, but which effectively terminates with the production of new viruses. Until then, it was thought that they also would control the infection with hepatitis A. However, after two tests in infected animals, it was found that poorly controlled and is earlier by CD4 + helper T, a different type of white blood cell that normally help killer T cell activation but was not thought that engage directed against infected cells. In two rats, the helper cells suppressed the growth of the virus without causing severe liver damage or inflammation.

In addition, they responded to the resurgence of hepatitis after the initial control of the infection, and remained strong until the virus was finally deleted from the liver of several months later.

"These findings document a role previously enjoyed by CD4 + T cells in resolving acute hepatitis A, and perhaps guard against a relapse in the growth of the virus and liver disease that sometimes occurs in people with weak immune systems, particularly the very young and old," said the study's lead author, MD Christopher M. Walker.

Source: Isaude.net
   Palavras-chave:   Hepatitis A    CD4 + T helper cells    White blood cells    Liver   
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