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publicado em 07/07/2012 às 18h00:00
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Pioneering research seeks to predict whether cancer treatment will be successful

Objective is to achieve more effective diagnosis for each case from a simple collection of blood from cancer patients

 
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Foto: Flickr/Hospital A.C.Camargo.
Department of Pathology, Hospital ACCamargo.
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Department of Pathology, Hospital ACCamargo.

Researchers ACCamargo Hospital in Sao Paulo, seeking, through a simple blood sample of cancer patients, predict whether a particular type of treatment will bring or not the most effective response for each case. Unprecedented in Brazil, the analysis of levels of circulating tumor cells had their first reports made over the past years by North American and European. The Brazilian project is being funded by FAPESP, which is investing 700,000 reais until May 2014.

The study is led by a pathologist and director of Anatomic Pathology, Fernando Augusto Soares, and also meets the director of medical oncology, Ludmilla Marcello researcher Dominic Fanelli and Chinen.

ACCamargo's goal is to achieve over the next two years counting CTCs in 230 patients to be treated at the Oncology Clinic, 100 diagnosed with colorectal cancer, 100 with lung cancer and another 30 with pancreatic cancer. It is believed that the spread of cancer requires the presence of CTCs.

Engage patients from 18 years with locally advanced disease or metastatic disease confirmed by pathologic analysis and / or radiation and also for patients who begin first-line chemotherapy for metastatic disease and with extent of disease determined by physical examination and imaging. Not included are patients with a prior history of another cancer within the past two years.

The research will be performed by collecting blood (plasma) from patients with solid tumors metastatic or locally advanced, with the negative control blood of healthy individuals and as positive control samples of blood with colon tumor cells maintained in culture. The patients blood is collected in three stages, the first prior to initiation of systemic therapy (chemotherapy, hormone therapy targeted therapies, among others), the second stage three to four weeks after initiation of treatment, and third repeating the each 9 or 12 weeks depending on the treatment.

Will be used by researchers ACCamargo Ariol system, which makes the cell separation by magnetic beads and identified by anti-cytokeratin antibody, making the negative selection with anti-CD45 (separation of leukocytes). Furthermore, it will use the ISET (Isolation by Size of Epithelial Tumor Cells), a direct method of enrichment of epithelial cells by filtration. "The simplicity provided by ISET prevents loss of rare cells in multiple steps of isolation. Once isolated, the CTCs can be characterized, for example, by immunocytochemistry or FISH analysis of molecules", said Ludmilla Chinen.

According to the researchers, the protocol aims to establish the methodology for counting CTCs may help guide treatment in different ways. "We want to correlate the levels of CTCs with imaging and be able to say whether the information generated with the clinician can better determine whether a particular therapy is working or not." Also according to them, there is the goal of bringing the reduction of imaging tests, which are costly and laborious and, therefore, only to follow up the patients by levels of CTCs. Finally, by observing the expression of markers / genes that are resistant to or not CTCs and its correlation with tumor expression and response, the researchers want to come to the conclusion about which is the most effective type of therapy for each patient, leading to an intelligent individualization of treatment.

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Source: Isaude.net
   Palavras-chave:   Cancer    Cancer    Analysis of the levels of tumor cells    ACCamargo Hospital    New York   
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