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publicado em 05/07/2012 às 13h06:00
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Study assesses impact of joint involvement in diabetes

Research developed at USP may determine specific treatments for patients with joint problems

 
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Foto: Marcos Santos/Usp Imagens
People with diabetes may experience joint stiffness
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People with diabetes may experience joint stiffness

A study at the Medical School of USP (USP) where there is impairment of the joints in diabetic rats. The researchers found fibrous tissue formation in the membrane that produces fluid lubricant to tendons and cartilage (synovium) and the predominance of thin fibers in the collagen network. From these notes, you can determine specific treatments.

In determining what is the impairment in articulation, we can carry out other works and define new therapeutic says the author of the work, the physical therapist Sandra Atayde. The amendment to the joint tissues of diabetic patients results in tendonitis and arthritis, causing pain, discomfort and stiffness, and may compromise mobility.

According to Sandra, there are studies showing that excess blood sugar compromises the joints, however, his work, directed by Professor Theodore Walcy Rosolia FMUSP identified what happens with collagen. The doctoral research was submitted in February 2012.

The amendment to the joint tissues of diabetic patients results in tendonitis and arthritis, causing pain, discomfort and stiffness, and may compromise mobility.

Diabetes mellitus is a disease characterized by the crisis in the metabolism of carbohydrates, lipids and proteins. According to 2007 data, the Department of Health Care, Brazil has nearly 6.5 million diabetics in the adult population and nearly 20% of the population over 65 years with the disease.

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In order to assess the impacts of the problem in the composition of structures such as articular cartilage, synovium, ligaments and tendons, we applied an experimental model in which rats were induced diabetes. To control the results, also used the non-diabetic rats, who shared the same tests of affected animals. In all test subjects of the experiment, we measured the collagen protein that provides support for these structures had some involvement.

The diabetic mice showed, on microscopic evaluation of its cartilaginous structures, tendon and ligament, a larger number of fine fibers in the collagen network, to the detriment of healthy rats. This remodeling of the fibers was influenced by the high rate of glucose in the blood picture that characterizes diabetes. In affected mice, the synovium showed formation of fibrosis (fibrous tissue), which affects blood flow and consequent nutrition of cartilage. There was also, replacement of collagen types in the structures, which can involve the small and large joints of people with diabetes.

Research on diabetes usually investigate only the effects of the disease in the propensity to cardiovascular, renal and eye, but the limited mobility decreases the possibility of people with diabetes manage their training and manage your weight, for example. For Sandra, his work influenced new research and facilitates the development of therapeutic strategies. His study group (Team Extracellular Matrix Laboratory of Rheumatology FMUSP) continues to develop studies on the subject from the end of your search.

Source: USP
   Palavras-chave:   Diabetes    Locomotion    Tendon    Cartilage    University of Sao Paulo    FMUSP   
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