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publicado em 09/06/2012 às 14h51:00
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Research turns possible to eliminate lethal bacterial resistance to antibiotics

"Armor 'newly identified protein may lead to new antibiotics can eliminate the bacteria Acinetobacter baumannii

 
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There' s new hope for development of an antibiotic that can put down a lethal " superbug" bacteria linked to the deaths of hundreds of hospital patients around the world, including a recent case at Edmonton' s Royal Alexandra Hospital.

Researchers from the University of Alberta-based Alberta Glycomics Centre found a chink in the molecular armour of the pathogen Acinetobacter baumannii. The bacteria first appeared in the 1970s and in the last decade it has developed a resistance to most antibiotics.

U of A microbiologist Mario Feldman identified a mechanism that allows Acinetobacter baumannii to cover its surface with molecules known as glycoproteins. That led the researchers to another discovery. " If the superbug cannot produce glycoproteins they become less virulent and less capable of forming biofilms," said Feldman. " The biofilm protects the bacteria from antibiotics."

Acinetobacter baumannii is a particularly insidious and contagious pathogenic bacteria that has plagued hospitals around the world. It spreads from one person to another by physical contact. The bacteria can live on hard surfaces for several days and can cling to hospital equipment like catheter tubes and inhalers. Acinetobacter infection is also spread by coughing and sneezing.

Hospital patients whose immune systems are already worn down are the most susceptible to the bacteria. It infects wounds and can spread to the lungs, blood and brain.

The researchers say more work is required to understand how the bacteria produce glycoproteins. " We' re hopeful our work will enable future development of drugs to interrupt the production of glycoproteins to weaken or eliminate the bacteria' s shield against antibiotics," said Feldman.

Feldman is a principal investigator for the Alberta Glycomics Centre at the U of A. The list of coauthors includes U of A graduate students Jeremy Iwashkiw and Brent Weber, and research colleagues in Ottawa, Austria and Australia. Their work was published June 7 in the journal PLoS Pathogens.

Source: UNIVERSITY OF ALBERTA
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Bacteria    molecular layer    Acinetobacter baumannii    antibiotic resistance    University of Alberta    Mario Feldmane   
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francisco de paula
posted on:
14/12/2012 16:43:10
MEU PAI SOFRE DE DPOC ESTÁ INTERNADO JA A 5 MESES. SAIU DA FASE CRITICA, MAS ENCONTRA-SE TRAQUEUSTOMIZADO. INFELIZMENTE TEM NA URINA A BACTERIA ACINETOBACCTER, O QUE NOS LEVA A CRER QUE EMBORA ESTEJA SO COLONIZADA, O QUE NÃO É PEQUENA.... ESTEJA INATIVA... DIZEM QUE NAO RESISTIRIA A ALCOOL... NAO SERIA INTERESSANTE O PACIENTE ABSORVER BEBIDA ALCOOLICA E ATORDOÁ-LA, E APOS, UTILIZAR-SE O ANTIBIOTICO ESPECIFICO? PARECE BRINCADEIRA A MINHA PERGUNTA NAO É MESMO? MAS NÃO É. ALIÁS O MEU PAI ESTÁ MUITO FRACO PARA ESSA ALTERNATIVA. MAS SE PUDEREM ME ORIENTAR COMO AUMENTAR A IMUNIDADE DELE, E/OU COMO AGIRA PARA PRESERVAR-LHE A VIDA , FICAREI IMENSAMENTE AGRADECIDO.
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