General
publicado em 05/06/2012 às 13h51:00
   Dê o seu voto:

Gene explains women's greater susceptibility of women with migraine

Region on the X chromosome that plays an important role in the disease can lead to better diagnostics and treatment

 
font size
A-
A+

New hope has arrived for migraine sufferers following a Griffith University study with the people of Norfolk Island.

Led by Professor Lyn Griffiths from the University's Griffith Health Institute, the team has identified a new region on the X chromosome as playing a role in migraine.

The research provides compelling evidence for a new migraine susceptibility gene involved in migraine. The study also indicated that there may be more than one X chromosomal gene involved and implicated a gene involved in iron regulation in the brain.

All females have two X chromosomes whilst males have an X and a Y chromosome.

"These results provide more support for the role of the X chromosome in migraine and may explain why so many more females suffer from the disorder," said Professor Griffiths.

Tracking down and identifying the various genes that cause migraine is very important as it provides insights to allow us to develop better means of diagnosis and more targeted treatments.

"Currently, 12 per cent of the population suffers from migraine. Even though we have some very good treatments for this very debilitating disease, they certainly don't work for everyone and can have some adverse side effects. Hence there is a real need to develop new migraine treatments."

This National Health and Medical Research Council funded work involved a unique population study of the remote Norfolk Island where 80 per cent of inhabitants are able to trace their ancestry back to the famous historical event, The Mutiny on the Bounty.

"This population was used due to its unusual pedigree structure in which genetic relationships can be traced through genealogical data to the island's original founders, and also the high incidence of migraine sufferers in this population. It's very useful for gene mapping purposes because of the reduced genetic and environmental diversity," said Professor Griffiths.

A comprehensive chromosome analysis of around 300 Norfolk participants from a large multigenerational Norfolk family, including many who are affected by migraine, was conducted using DNA samples obtained from the islanders.

Source: Isaude.net
   Palavras-chave:   Migraine    Headache    Gene    Chromosome X    Lyn Griffiths    Griffith University's Health Institute   
  • Share this pageShare this page
  • Share this pageCorrect
  • ShareShare
  • AlertAlert
Reduced link: 
  • You are recommending this story: Gene explains women's greater susceptibility of women with migraine
  • Fill in the following form to send your recommendation to your friend:

  • You are suggesting a correction for this story: Gene explains women's greater susceptibility of women with migraine


Receba notícias do iSaúde no seu e-mail de acordo com os assuntos de seu interesse.
Seu nome:
Seu email:
Desejo receber um alerta com estes assuntos:
Migraine    headache    gene    chromosome X    Lyn Griffiths    Griffith University's Health Institute   
Comments:
Comment
Leave your comment
Close
(Required fields are marked with an *)

(Your email address will never be published or shared.)

Enter the letters and numbers below and click in the button "send"

  • Twitter iSaúde
advertising
Informe Saúde printed version

Recommend the portal
Close [X]
  • You are recommending this story: http://www.isaude.net
  • Fill in the following form to send your recommendation to your friend:

RSS news from the portal  iSaúde.net
Get the newsletter of the portal  iSaúde.net
Recommend the portal iSaúde.net
News from  iSaúde.net in your blog or website.
Get news on the subject of your interest.
© 2000-2011 www.isaude.net Todos os direitos reservados.