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publicado em 21/03/2010 às 14h00:00
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The cancer drug can prevent relapses in cocaine users

Study of the University of California, suggests that sodium butyrate can help with behavioral therapy

 
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Foto: Daniel A. Anderson / Univ. Califórnia - Irvine
Scientists Marcelo Wood (pictured), Melissa Malvaez, and colleagues found that a drug in development to treat cancer, could facilitate a behavioral therapy for cocaine addicts
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Scientists Marcelo Wood (pictured), Melissa Malvaez, and colleagues found that a drug in development to treat cancer, could facilitate a behavioral therapy for cocaine addicts

A survey conducted by UC Irvine neuroscientists indicates that a drug in development to treat cancer might help prevent the recurrence of drug use in people who are trying to overcome cocaine addiction.

Tests in mice conditioned to cocaine showed that demand was inhibited by the drug more rapidly and to a greater extent with administration of sodium butyrate.

According to the scientists, people who abuse cocaine typically receive behavioral therapy for closure, they learn with time and without medication, a drug to dissociate from the contexts and suggestions associated with it. However, the process is lengthy and often leave the participants.

"Our findings are exciting because the action of sodium butyrate on fundamental molecular mechanisms, provided a new approach to understanding and treatment of drug addiction," said professor and co-author of the study, Marcelo Wood.

In the experiment conducted to prove the thesis student Melissa Wood and Malvaez rats placed in a container with three distinct chambers. They received cocaine in a particular camera, and quickly developed a preference for that location.

So cocaine was broken, and some of the mice were treated with sodium butyrate. Within 24 hours, the mice no longer sought the chamber of cocaine, but those who were not treated with the drug took more than a week to stop looking for the particular location.

Later on, cocaine was again administered, before entering the chamber. The treated mice continued to show no preference, but not treated quickly sought the chamber of cocaine.

In previous studies the same group found that sodium butyrate, a histone deacetylase (HDAC) may improve the long-term memory. HDAC inhibitors relax the protein structure that organizes and compacts genomic DNA, allowing for easy maintenance and activation of genes involved in memory storage.

"As the sodium butyrate acts at this level their effects can be much more stable" than other compounds, finished Wood

The study, published in September by the journal Biological Psychiatry, was funded by the National Institute against Drug Abuse (NIDA sila in English) and National Institute of Mental Health (NIMH).

Source: UNIVERSIDADE DA CALIFÓRNIA
   Palavras-chave:   Cancer    Cocaine    Relapse    Sodium butyrate    Marcelo Wood    Melissa Malvaez    HDAC      
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