Science and Technology
publicado em 12/10/2011 às 14h30:00
   Dê o seu voto:

Biomedical USP seek cure for infection that paralyzes the lower limbs

Number of patients infected with HTLV-1 is around 10 to 20 million worldwide and 3% to 5% develop paralysis

 
font size
A-
A+

Some pieces of information on this page may have been automatically translated. Makernews is not responsible for the irregularities resulting from these translations. When in doubt,      consult the original text.



Scientists from the Faculty of Pharmaceutical Sciences of Ribeirão Preto (FCFRP) USP seek to understand the mechanisms of HAM / TSP, an infectious disease characterized by paralysis of the lower limbs, among other symptoms. The biomedical Tomazini Mariana Pinto explains that the disease is caused by HTLV type 1 virus, HTLV-1. The number of patients infected with HTLV-1 is around 10 to 20 million people around the world. Our studies aim to understand why only between 3% and 5% of them develop HAM / TSP, explains.

Investigations have revealed FMRP in, for example, that genes Paxilina, CXCR4, IL-27, granzyme A, and FOXP3 Perfurina are expressed differently in people infected CD4 T lymphocytes by HTLV-1. The survey results suggest that these genes may have some sort of influence on the development of the disease.

Mariana said that while people infected with the virus and HAM / TSP present an increased expression of genes Paxilina, CXCR4, IL-27, granzyme A, and Perfurina FOXP3 is not correct to say that cause disease, as they may be associated with other diseases. Our objective in this research was to determine the genes that were differentially expressed between the groups infected and not infected with HTLV-1 in an attempt to understand the development of HAM / TSP, he added.

According to Mariana, the human immune system, dendritic cells recognize viruses and other invaders and present them to CD4 T lymphocytes. These lymphocytes in turn produce various factors and cytokines that cause the immune response. Just as HIV (the virus that causes AIDS), HTLV-1 is transmitted through contaminated blood, sexual relations with infected people without using condoms, the sharing of syringes with the virus, and infected mother to child during pregnancy and / or childbirth. And, like AIDS, also there is no cure.

The study was conducted using a technique called microarray analysis that allowed for blood samples, 44 000 genes in three groups of people: This study comprised 28 healthy individuals, 26 asymptomatic and 21 patients with HAM / TSP, informs biomedical. Patients infected with HTLV-1 are accompanied in Tropical Neurology Clinic of the Hospital das Clinicas, Faculty of Medicine of Ribeirão Preto (HCFMRP) USP.

The results showed that people infected with HIV have an increased expression of genes Paxilina, CXCR4, IL-27, granzyme A, and Perfurina FOXP3, compared to the control group (healthy). The IL-27 gene was more expressed in asymptomatic persons. We now intend to start other two projects, one involving IL-27 gene to understand its role for the non-development of HAM / TSP, and another with Paxilina because it is rarely described in the scientific community in relation to HTLV he says.

The Paxilina and CXCR4 are linked to cell migration, IL-27 is linked to virus replication, the granzyme A, Perfurina are related to cell death, and FOXP3 is a marker of a subtype of T cells, regulatory T cells, working in the immune response.

Mariana's research was supported by the Coordination for the Improvement of Higher Education Personnel (Capes) and was developed at the Blood Center of Ribeirão Preto. The biomedical studied the subject in his master's gene expression profile of CD4 T lymphocytes in HTLV-1, presented in early August in FCFRP under the guidance of Professor Simone Kashima, the Blood Center of Ribeirão Preto.

Source: USP
   Palavras-chave:   Faculty of Pharmaceutical Sciences    Ribeirão Preto    USP    HAM / TSP    Infectious disease    Paralysis    Lower limbs    Research    Study    Mariana Tomazini Pinto    Viruses    HTLV   
  • Share this pageShare this page
  • Share this pageCorrect
  • ShareShare
  • AlertAlert
Reduced link: 
  • You are recommending this story: Biomedical USP seek cure for infection that paralyzes the lower limbs
  • Fill in the following form to send your recommendation to your friend:

  • You are suggesting a correction for this story: Biomedical USP seek cure for infection that paralyzes the lower limbs


Receba notícias do iSaúde no seu e-mail de acordo com os assuntos de seu interesse.
Seu nome:
Seu email:
Desejo receber um alerta com estes assuntos:
Faculty of Pharmaceutical Sciences    Ribeirão Preto    USP    HAM / TSP    infectious disease    paralysis    lower limbs    research    study    Mariana Tomazini Pinto    viruses    HTLV   
Comments:
Comment
Leave your comment
Close
(Required fields are marked with an *)

(Your email address will never be published or shared.)

Enter the letters and numbers below and click in the button "send"

  • Twitter iSaúde
advertising
Informe Saúde printed version

Recommend the portal
Close [X]
  • You are recommending this story: http://www.isaude.net
  • Fill in the following form to send your recommendation to your friend:

RSS news from the portal  iSaúde.net
Get the newsletter of the portal  iSaúde.net
Recommend the portal iSaúde.net
News from  iSaúde.net in your blog or website.
Get news on the subject of your interest.
© 2000-2011 www.isaude.net Todos os direitos reservados.