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publicado em 06/10/2011 às 13h45:00
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Sociability is related to brain cells generated in adolescence

Mice become profoundly anti-social when creating new brain cells is interrupted in adolescence

 
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Rats become extremely anti-social when creating new brain cells is interrupted in adolescence. Discovery may help researchers understand conditions such as schizophrenia and other mental disorders.

The study conducted by Yale University in the United States, he noted that even when the process is interrupted in adults, these behavioral changes are not observed.

"This has important implications for understanding social development at the molecular level," said Arie Kaffman, assistant professor of psychiatry and lead author of the study.

Scientists have long known that new brain cells are continuously generated in specific regions of the brain after birth. This process, called neurogenesis, occurs at a significantly higher rate during childhood and adolescence than in adulthood, but most research has focused on the function of these neurons in older brains.

The Yale team decided to explore the function of these new brain cells in rats of different ages. Normal adult mice tend to spend much time exploring and interacting with strangers rats. However, adult mice that had blocked neurogenesis during adolescence showed no interest in exploring other adult mice and even ran away from social interactions with other mice.

"These mice acted as if they did not recognize the other rats." Kaffman said.

The blockade of adult neurogenesis had no effect on social behavior, suggesting that the cells of the brain during adolescence generate a very different contribution to brain function and behavior in adulthood, say the scientists.

Interestingly, schizophrenics have a deficit in the generation of new neurons in the hippocampus, an area of ​​the brain where new neurons are created. Because the symptoms of schizophrenia first appear in adolescence, and it is possible that deficits in the generation of new neurons during adolescence in childhood or even generate new insights into the development of some of the social and cognitive deficits seen in this disease, "concludes Kaffman.

Source: Isaude.net
   Palavras-chave:   Mice    Brain cells    Schizophrenia    Research    Yale University   
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