Science and Technology
publicado em 06/10/2011 às 19h36:00
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Discovered reason that fat cells lose their function

Study reveals mechanism that causes fat cells lose their ability to store and use energy

 
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Foto: Gladstone Institutes
Fares Robert Jr., of Gladstone Institutes researcher who is working in conjunction with the laboratory Tobias Walther
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Fares Robert Jr., of Gladstone Institutes researcher who is working in conjunction with the laboratory Tobias Walther

Researchers from Yale University in the United States, found one of the mechanisms that cause fat cells lose their ability to store and use energy, which until then was a mitério science that contributes to a serious public health problem, the obesity.

The Yale team has discovered a mechanism that allows fat droplets expand when metabolic energy is in excess - that is, if it is eaten more food than the body can burn, helping in the transformation of the end products of fatty acids in our food . The obese suffer from some health problems when the fat cells can no longer do this work.

"Tens of things go wrong at the same time when cells are overwhelmed by excess fat storage. The question that begs is: Which of these factors cause the breakdown of cellular balance?" Walther said Tobias, assistant professor of cell biology and senior author of the study.

The Laboratory of Walther and colleagues from the Gladstone Institute of San Francisco found that an enzyme within the cells of the surface tension of the fat droplets in expansion. This triggers the production of more components of the surface of lipid droplets, allowing them to expand and accommodate more fatty acids without adverse consequences. This process is crucial to the fat cells remain in harmony with their environment.

Walther said that there are probably many such mechanisms that regulate energy intake and expenditure as the food is ingested.

"Cells must balance the fluctuations in the availability of energy and we are exploring other mechanisms that help maintain the dynamic storage capacity," he said.

"By showing exactly how our cells are supposed to store individual fat molecules, our research offers clues about what happens when things go wrong and fat accumulates in the body," said Dr. Robert Fares Jr., senior researcher of the Institute Gladstone.

Source: Isaude.net
   Palavras-chave:   Fat cells    Energy metabolism    Research    Yale University   
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