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publicado em 08/09/2011 às 17h57:00
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Fluorescent sensor detects activity of proteins involved in cancer

New procedure measures the concentration of transcription factors in biological samples quickly and easily

 
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U.S. researchers published in the Journal of the American Chemical Society the discovery of a new approach able to detect the activity of proteins that bind to DNA and the genes that allow cells to grow normally or become cancerous.

The new fluorescent sensors based procedure is faster than current methods and has potential to help in the detection and treatment of diseases such as cancer.

The research team, led by Kevin Plaxco and Francesco Ricci, noted that more than 10% of 25 000 to 30 000 genes in the human body contain instructions for the manufacture of DNA binding - proteins. Most of these proteins regulates the transcription factors (TF). They start or stop the first step in the process when the instructions of the gene are put into action. TFS are associated with DNA and genes on or off. Understanding and measuring the activity of these factors is important because they are involved in health and disease, for example, in many cancers.

The existing forms to detect the activity of TFS are slow and heavy. To overcome these barriers, researchers have developed a new test called transcription factor flags. "

They said the flags detect the activity and concentration of TFS directly in biological samples, from a dark state to a fluorescent state by binding to a specific TF.

The results showed that use flags of TF is simpler and faster than current methods, and that the new approach may have multiple uses in cancer diagnosis and the search for drugs against the disease.

Source: Isaude.net
   Palavras-chave:   Fluorescent sensor    Transcription factors    Cancer    American Chemical Society    Kevin Plaxco   
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