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publicado em 03/09/2011 às 09h46:00
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Formula predicts chance of being alive one year after receiving a heart transplant

Scale can help doctors find out which people would be benefited and help guide decisions on organ allocation

 
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Foto: Johns Hopkins Medicine
John V. Conte. senior author of the study
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John V. Conte. senior author of the study

Researchers at Johns Hopkins University, USA, developed a formula to predict which patients underwent a heart transplant are at increased risk of death one year after surgery. The tool can help medical teams to discover which people benefit most from the decisions and guide the allocation of organs.

The research team, led by John V. Conte, met a number of risk factors already associated with poor outcomes, such as age, race and sex and then assigned a number of points for each factor. The sum of these items created a scale. The higher the score, the greater the risk of death one year after transplantation.

Some factors were weighted more heavily than others, such as being female (three points), african-american descent (three points), and the need for dialysis before the operation (five points).

Patients with the lowest score - between zero and two - had 92.5% chance of being alive 12 months after surgery. Those with a score above 20 points had 50% chances. Each additional point on the scale increased the odds of death in 14%. To develop and test the validity of the scale, called IMPACT, Conte's team analyzed data on 21,378 heart transplants performed in the United States between 1987 and 2010.

The researchers said more research is needed to know about the role played by other factors related to the donor organ. The study results suggest, for example, that an organ from a donor aged 50 years or has remained outside the body for more than four hours also increases the risk of death receptor. The incorporation of scores generated by the scale IMPACT bring another dimension to the choice of who should receive a heart transplant, said Conte.

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Source: Isaude.net
   Palavras-chave:   Heart transplant    Heart formula    Scale    Research    Johns Hopkins University    John V. Count   
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