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publicado em 16/08/2011 às 16h23:00
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Biologists focus on protein that may help treat obesity and diabetes

New protein may be essential to keep your appetite under control and have the rate of blood sugar

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A newly identified protein may be key to keep your appetite under control and have the rate of blood sugar, according to a study by researchers from York.

Professor of biology specializing in neuroendocrinology, Suraj Unniappan, is investigating the metabolic effects of a protein called nesfatin-1, abundant in the brain. His studies found that mice administered with nesfatin-1 ate less, used more stored fat and were more active. Furthermore, the protein stimulates insulin secretion by pancreatic beta cells of rats and mice.

"Really, the rats ate more frequently but in smaller quantities. Moreover, they were more active and found that fatty acid oxidation was increased them. In other words, the energy reserve that is preferentially used during treatment nesfatin-1 was the fat. This suggests a greater loss of it, which could eventually result in weight loss, "says a member of York's neuroscience graduate degree program, and recipient of the Canadian Institutes of Health Research (CIHR ) New Investigator Award, Unniappan.

The findings were published in two recent articles in the research laboratory Unniappan: one published today in Endocrinology and another in March 2011 in the Journal of Endocrinology. Discovered by a research team from Japan in 2006, nesfatin-1 was previously found to regulate appetite and fat production when injected into the brains of mice and rats.

Unniappan's findings indicate that the protein stimulates the secretion of insulin from the pancreas, a glandular organ that contains clusters of cells called islets of Langerhans. These islands have produced several important hormones, including hormone-primary hypoglycemic, insulin. Previously, the team Unniappan studied rats and found similar results. Insulin secretion was not only encouraged, but nesfatin-1 was also observed to be lowered in the pancreatic islets of rats with type 1 diabetes and increased in those with type 2 diabetes. In Type 1 diabetes, the body does not produce more insulin due to destruction of cells within the pancreas. In type 2 diabetes, the body has become resistant to insulin and resulted in obesity. Unniappan The research, conducted at the Laboratory of Neuroendocrinology in the Integrative Biology Department at York, focuses on identifying and analyzing the biological effects of the gut, regulation of appetite and metabolic hormones in fish and mammals.

"We call it 'brain-gut axis. While the brain is involved in many factors that regulate our energy balance, the intestine is also responsible for many neural and endocrine signals responsible? To regulate sugar levels, satiety, of hunger and blood. The big question we're trying to solve is how these peptides interact and network with other peptides in the endocrine system - which is so complex - in order to maintain constant body weight and blood glucose levels, "says Unniappan.

A better understanding of brain-gut axis could contribute to developing the potential of pharmacological interventions for diabetes and obesity. "New treatments based on hormones, which suppress the body weight and blood sugar, it would be desirable. However, we are far from developing nesfatin-1 as a molecule. Our current research focuses on further exploring the therapeutic potential of nesfatin-1 in metabolic diseases with debilitating complications, "says Unniappan. The author of both publications is a graduate doctoral student lab Unniappan, Ronald Gonzalez. The survey was conducted in collaboration with the co-author and professor Robert Tsushima York and Rolando Cedd. Unniappan's research is supported by grants from the Canada Foundation for Innovation (CFI), the Ontario Ministry of Research and Innovation, and the James H. Cummings Foundation.

   Palavras-chave:   Protein    Blood sugar    Appetite    Brain    Diabetes    Obesity    Fat    Findings    Suraj Unniappan    Canadian Institutes of Health Research   
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