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publicado em 16/07/2011 às 15h00:00
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Microstructure of bacteria is tested as a vaccine against pneumonic plague

A subunit found in the actual organism causing the disease may stimulate the immune system response

 
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Foto: trudeauinstitute.org
Drs. George Coukos, lider da pesquisa, Bruce Levine e a enfermeira Linda Smith
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Drs. George Coukos, lider da pesquisa, Bruce Levine e a enfermeira Linda Smith

Researchers at the lab Smiley, connected to the Trudeau Institute, USA, have identified a component of the bacterium that causes plague that can be used as a vaccine. This "subunit" could be used to create a safe way of stimulating T lymphocytes vaccine against pneumonic plague. "To date, there has been little progress in developing safe and effective vaccines against the plague or biological weapons against similar. Our data identify a single component of the bacterium that causes plague and is noticed by T lymphocytes This could be a discovery- key as we seek to develop a vaccine against the plague, "says Stephen Smiley.

The laboratory provides that this subunit may be added to other study because of the ability to induce antibody responses. Together, these multiple subunits could lead to safety and antibody responses of T lymphocytes, best fighting the plague.

According to Smiley, there is a pneumonic plague vaccine licensed in the United States. Along with Jr-Shiuan Lin, he works to develop an immunization can protect members of the armed forces and people in general a plague bomb. The disease is caused by Yersinia pestis, possibly the most lethal bacteria known to man. The infection of the lung, known as pneumonic plague, is extremely lethal and usually leads to death within a week.

For Smiley, it can be a major breakthrough in the battle to develop a vaccine against the plague and possible terrorist attacks. Many of the concerns related to high-priority bioterror are caused by bacteria that cause acute infection of the lung, such as tularemia, anthrax and plague.

Most potential vaccines against plague study aims to stimulate B cells to produce antibodies. However, animal tests suggest that antibodies may not be sufficient to protect humans from the pneumonic plague. Smiley The laboratory has shown that T cells can also fight the disease. The laboratory has already shown that immunization with the vaccine stimulates the production of T lymphocytes that provide partial protection. This vaccine consisted of a live version, but weakened form of bacteria that causes plague.

Live vaccines are generally effective but can be difficult to obtain a license, they have the potential to grow in immunocompromised recipients and inadvertently cause the disease.

In addition, Smiley believes that these studies help to fight other types of pneumonia. "Bacterial pneumonia is a common cause of death in hospitals and, like the plague, many of these pneumonias are caused by bacteria, to be addressed, may require both antibody and T cells," says the researcher.

Source: Isaude.net
   Palavras-chave:   Pneumonic plague    Pneumonia    Bio-terror    T lymphocytes    Biological weapons   
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