Science and Technology
publicado em 04/07/2011 às 17h00:00
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Antibiotic gives hope to children and adolescents with early aging

Rapamycin may reduce levels of toxic protein progerina cells of children who have the disease

 
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Foto: Reprodução/Brow University
Sam junto à sua mãe, Leslie Gordon
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Sam junto à sua mãe, Leslie Gordon

A study conducted at Brown University shows that the antibiotic rapamycin may, in part, to rid the cells of a protein that causes progeria, a rare genetic disorder that leads to premature aging and fatal cardiovascular disease in children.

For over a decade, a professor of pediatrics Leslie B. Gordon - mother of Sam, a 14 year old boy who has the disease - has been at the forefront of producing and promoting research. The study was partially funded by the Progeria Research Foundation (an institution which Gordon helped establish) and shows that the antibiotic rapamycin can decrease levels of toxic protein progerina cells of children with progeria.

The discovery of rapamycin can still lead to clinical trials, but the Collins team conducted their research with progeria cells in the laboratory. Gordon says it's not a coincidence that a drug such as rapamycin, which has been shown to extend life span in rats without progeria, may also be useful against the disease. All people produce some progerina, which accumulates with age. The progeria, therefore, is directly related to normal aging and cardiovascular consequences of it.

"The Progeria informed us about the natural process of aging on cardiovascular diseases of aging in ways we never could have understood if not observássemos children with progeria, if we cared about them. This is a perfect reason to fund research on rare disease, although only about 250 children worldwide have progeria, "says Gordon.

The progress against the disease in the 11 years since the Progeria Research Foundation was created has been huge. There was no hope for the families, there was no hope that we could help children with progeria, this 100% fatal disease of premature aging. Our progress is absolutely amazing, says the pediatrician.

Pesquisadora Leslie B. Gordon comenta sobre os resultados do estudo

Spain

Source: Isaude.net
   Palavras-chave:   Progeria    A disease of premature aging    Rapamycin    Toxic protein    Progerina   
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