General
publicado em 01/07/2011 às 21h00:00
   Dê o seu voto:

Retinoic acid improves efficacy of vaccines against deadly diarrhea

Substance contributes to immune cells reach the intestinal mucosa where they produce antibodies to neutralize germs

EFE  
font size
A-
A+

Some pieces of information on this page may have been automatically translated. Makernews is not responsible for the irregularities resulting from these translations. When in doubt,      consult the original text.



Experts at the Medical School of Hannover (MHH), Germany, said on Friday (01) who developed a new vaccination strategy consisting of retinoic acid added to vaccines to fight germs that cause diarrhea deadly pathogens.

After a series of tests on mice, scientists have concluded that the vaccines against cholera and salmonellosis are significantly more effective when it contains this type of acid, which contributes to the immune cells reach the intestinal mucosa where they produce antibodies to neutralize the germs.

"This innovative vaccination strategy is of great importance, not only with regard to the bacterium E. coli, but especially diarrhea affecting children in developing countries," said Reinhold Förster, Immunology, Faculty of FMM.

According to the researcher, "many vaccines do not work well in developing countries and this is due to malnutrition, especially to vitamin A," responsible for the production of retinoic acid.

The role of acid in the immune process was discovered only a few years ago, why had not yet attempted to enforce its use in vaccines.

During the tests, the scientists injected vaccines against salmonellosis and cholera in two groups of rats and the same with retinoic acid to the other two groups and then fed the animals with salmonella and cholera toxins.

"The groups that had received vaccines with retinoic acid in both cases were significantly better protected," said Forster.

On expert opinion, this new vaccination strategy has great potential. "Now exists the possibility immunization more effective against all germs pathogens causing diarrhea" considered adding scientists should apply these results in rotavirus vaccines in developing.

Diarrhea represent 20% of the causes of mortality in children under 5 in developing countries, according to the World Health Organization

The pathogens, however, also constitute a permanent threat in industrialized countries, as was demonstrated during the recent outbreaks of E. coli in Germany that caused at least 48 deaths across the country.

Brazil

Source: EFE
   Palavras-chave:   Diarrhea    Vaccine    Retinoic acid    School of Medicine    Hannover    Germany    Cholera    Salmonellosis   
  • Share this pageShare this page
  • Share this pageCorrect
  • ShareShare
  • AlertAlert
Reduced link: 
  • You are recommending this story: Retinoic acid improves efficacy of vaccines against deadly diarrhea
  • Fill in the following form to send your recommendation to your friend:

  • You are suggesting a correction for this story: Retinoic acid improves efficacy of vaccines against deadly diarrhea


Receba notícias do iSaúde no seu e-mail de acordo com os assuntos de seu interesse.
Seu nome:
Seu email:
Desejo receber um alerta com estes assuntos:
diarrhea    vaccine    retinoic acid    School of Medicine    Hannover    Germany    cholera    salmonellosis   
Comments:
Comment
Leave your comment
Close
(Required fields are marked with an *)

(Your email address will never be published or shared.)

Enter the letters and numbers below and click in the button "send"

  • Twitter iSaúde
advertising
Informe Saúde printed version

Recommend the portal
Close [X]
  • You are recommending this story: http://www.isaude.net
  • Fill in the following form to send your recommendation to your friend:

RSS news from the portal  iSaúde.net
Get the newsletter of the portal  iSaúde.net
Recommend the portal iSaúde.net
News from  iSaúde.net in your blog or website.
Get news on the subject of your interest.
© 2000-2011 www.isaude.net Todos os direitos reservados.