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publicado em 25/05/2011 às 17h34:00
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Enzyme that regulates heart rhythm points preventing sudden death in athletes

Study suggests that MKK4 enzyme helps prevent arrhythmias and can be regulated to prevent cardiac arrest

 
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And Xperiment laboratory and computer simulations have helped researchers to demonstrate that MKK4 enzyme is involved in prevention of cardiac arrhythmias. They believe that this modified enzyme that another protein, connexin, which forms an electrical bridge between the adjacent heart cells to ensure conduction of electrical activity in the whole heart, like a wave of excitement, causing the synchronous mechanical contraction of the heart with a regular rhythm of heartbeat.

A major cause of arrhythmias is cardiac hypertrophy. It happens when a part of the heart muscle thickens without an apparent cause. C omumente associated with hypertension and excessive exercise, this condition decreases the heart chamber zo and reduce the volume of blood pumping. Arrhythmias cause millions of deaths annually worldwide and is perhaps the best known cause of sudden cardiac arrest in young people who play sports.

The multidisciplinary team found that the loss of MKK4 protein disrupts the spatial distribution of connexin, resulting in reduced electrical coupling between uniform and non-heart cells. Is to cause a wave of excitement in the heart fragmented, leading to uncoordinated contraction of heart muscle and irregular rhythm. As a result, the heart loses its efficiency to pump blood, causing a sudden disability or death.

Using measurements experiment together with the detailed models, we could simulate the electrical activity of heart tissue with impaired electrical coupling between adjacent cells heart. The information generated from this study will help us identify the enzyme MKK4 could become a therapeutic target for the treatment of cardiac arrhythmias in association with cardiac hypertrophy, the researcher explains Wang Xin.

This research indicates that it was possible to identify the most important factor behind the sudden death associated with cardiac hypertrophy, which can affect people of any age with hypertension and healthy athletes also well-trained biophysicist Henggui said Zhang, who also participated in the survey.

Source: Isaude.net
   Palavras-chave:   Cardiac hypertrophy    High blood pressure    Arrhythmia    Heart muscle    Sudden death    MKK4   
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